QuickView for LAG3 (gene)
- Gene Symbol:
- LAG3
Homo sapiens - Full name:
- lymphocyte activating 3
- Synonyms:
- CD223, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3
- Genomic Location:
- Chr 12: 6751931-6757880
- Description:
-
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGGAAA_NFAT_Q4_01 , RTAAACA_FREAC2_01 , RYTTCCTG_ETS2_B , VDR_Q3 , STAT6_02 , HFH1_01 , PEA3_Q6 , AREB6_04 , GGGAGGRR_MAZ_Q6 , FOXO3_01
- Cytogenetic Map:
-
12p13.31
GO Molecular Function
MHC protein binding | transmembrane signaling receptor activity | signaling receptor binding | signaling receptor activity | antigen binding | protein binding | MHC class II protein binding
GO Biological Process
positive regulation of immune response | negative regulation of leukocyte activation | positive regulation of cell killing | negative regulation of immune system process | antigen processing and presentation | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | regulation of leukocyte mediated cytotoxicity | cellular process | regulation of cytokine biosynthetic process | positive regulation of immune effector process | negative regulation of cellular metabolic process | regulation of immune response | regulation of cellular process | regulation of metabolic process | positive regulation of natural killer cell mediated immunity | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | negative regulation of cell adhesion | negative regulation of lymphocyte activation | antigen processing and presentation of exogenous peptide antigen via MHC class II | negative regulation of metabolic process | regulation of cell adhesion | regulation of interleukin-2 biosynthetic process | antigen processing and presentation of peptide antigen via MHC class II | regulation of T cell activation | negative regulation of cytokine production | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | negative regulation of cytokine biosynthetic process | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | negative regulation of cell activation | regulation of protein metabolic process | negative regulation of interleukin-2 production | antigen processing and presentation of exogenous antigen | regulation of innate immune response | negative regulation of interleukin-2 biosynthetic process | cell surface receptor signaling pathway | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | negative regulation of biosynthetic process | regulation of cell activation | positive regulation of natural killer cell mediated cytotoxicity | regulation of natural killer cell mediated cytotoxicity | negative regulation of protein metabolic process | signaling | regulation of cytokine production | regulation of cell-cell adhesion | positive regulation of leukocyte mediated cytotoxicity | antigen processing and presentation of peptide antigen | immune system process | regulation of natural killer cell mediated immunity | signal transduction
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | external side of plasma membrane | plasma membrane | cell periphery | cell surface | membrane
