QuickView for LAMC1 (gene)

Gene Symbol:

LAMC1 Homo sapiens

Full name:

laminin subunit gamma 1

Synonyms:

LAMB2, laminin subunit gamma-1, S-LAM gamma, S-laminin subunit gamma, laminin B2 chain, laminin, gamma 1 (formerly LAMB2), laminin-10 subunit gamma, laminin-11 subunit gamma, laminin-2 subunit gamma, laminin-3 subunit gamma, laminin-4 subunit gamma, laminin-6 subunit gamma, laminin-7 subunit gamma, laminin-8 subunit gamma, laminin-9 subunit gamma

Genomic Location:

Chr 1: 181259218-181381350

Description:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, b...

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Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  TGANTCA_AP1_C ,  TTTGCAG_MIR518A2 ,  ACACTCC_MIR122A ,  HFH1_01 ,  CTATGCA_MIR153 ,  PEA3_Q6 ,  TGTGTGA_MIR377 ,  TGAGATT_MIR216 ,  AP1_Q6 ,  IRF1_Q6 ,  NFE2_01 ,  AP1_Q6_01 ,  ATCATGA_MIR433 ,  TEF1_Q6 ,  AP1_01 ,  AP1FJ_Q2 ,  TGCCTTA_MIR124A ,  GTGCCAA_MIR96 ,  MGGAAGTG_GABP_B ,  NRF2_Q4 ,  AP1_Q4 ,  GTGCCTT_MIR506 ,  TCTATGA_MIR376A_MIR376B ,  GGCAGCT_MIR22 ,  BACH1_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AFP1_Q6 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  AP1_Q2 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  CTAGGAA_MIR384 ,  ATGAAGG_MIR205 ,  AP1_Q4_01 ,  ACACTGG_MIR199A_MIR199B ,  TCF11MAFG_01 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-376 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-496

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miRNA binding sites
(Source: miRecords):

hsa-miR-29c Targeted Genes ,  hsa-miR-124 Targeted Genes

Cytogenetic Map:

1q25.3

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