QuickView for LATS1 (gene)

Gene Symbol:

LATS1 Homo sapiens

Full name:

large tumor suppressor kinase 1

Synonyms:

WARTS, wts, serine/threonine-protein kinase LATS1, LATS (large tumor suppressor, Drosophila) homolog 1, LATS, large tumor suppressor, homolog 1, WARTS protein kinase, h-warts, large tumor suppressor homolog 1

Genomic Location:

Chr 6: 150023744-150081085

Description:

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein bin...

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The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAAGGGA_MIR204_MIR211 ,  ATGTTAA_MIR302C ,  AAAGACA_MIR511

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

6q25.1

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