QuickView for LCP1 (gene)

Gene Symbol:

LCP1 Homo sapiens

Full name:

lymphocyte cytosolic protein 1

Synonyms:

CP64, HEL-S-37, L-PLASTIN, LC64P, LPL, PLS2, plastin-2, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P), LCP-1, Lymphocyte cytosolic protein-1 (plasmin), bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)), epididymis secretory protein Li 37

Genomic Location:

Chr 13: 45598060-45654395

Description:

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in ...

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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  AAGCCAT_MIR135A_MIR135B ,  ETS_Q4 ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  AREB6_02 ,  RSRFC4_01 ,  TEL2_Q6 ,  TATAAA_TATA_01 ,  CDP_02 ,  SREBP1_01 ,  CAGGTG_E12_Q6 ,  ETS2_B ,  GTGCCAA_MIR96 ,  S8_01 ,  MGGAAGTG_GABP_B ,  ELK1_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  SRF_Q5_01 ,  TGATTTRY_GFI1_01 ,  ER_Q6_02 ,  ER_Q6_01 ,  ER_Q6 ,  ETS1_B ,  SRF_C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-96

Cytogenetic Map:

13q14.13

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