QuickView for LCT (gene)

Gene Symbol:

LCT Homo sapiens

Full name:

lactase

Synonyms:

LAC, LPH, LPH1, lactase-phlorizin hydrolase, lactase-glycosylceramidase, lactase-phlorizin hydrolase-1

Genomic Location:

Chr 2: 136261885-136311220

Description:

The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in this gene are associated with congenital lactase de...

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The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in this gene are associated with congenital lactase deficiency. Polymorphisms in this gene are associated with lactase persistence, in which intestinal lactase activity persists at childhood levels into adulthood.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HP1SITEFACTOR_Q6 ,  RGTTAMWNATT_HNF1_01

Cytogenetic Map:

2q21.3

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