QuickView for LDB2 (gene)

Gene Symbol:

LDB2 Homo sapiens

Full name:

LIM domain binding 2

Synonyms:

CLIM1, LDB-2, LDB1, LIM domain-binding protein 2, LIM binding domain 2, LIM domain-binding factor CLIM1, LIM domain-binding factor-2, carboxyl-terminal LIM domain-binding protein 1

Genomic Location:

Chr 4: 16112262-16509425

Description:

The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory comple...

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The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  IRF1_01 ,  OCT1_07 ,  OCT1_05 ,  OCT1_B ,  RYTTCCTG_ETS2_B ,  OCT1_04 ,  EFC_Q6 ,  FOXO4_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  NFY_C ,  EVI1_04 ,  YNTTTNNNANGCARM_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  RYCACNNRNNRNCAG_UNKNOWN ,  OCT1_Q5_01 ,  OCT_C ,  WTGAAAT_UNKNOWN ,  TATAAA_TATA_01 ,  AR_Q6 ,  OCT1_Q6 ,  PAX4_02 ,  FOXO3_01 ,  CAGGTA_AREB6_01 ,  CATGTAA_MIR496 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  ETS2_B ,  LHX3_01 ,  TATA_C ,  CCAWYNNGAAR_UNKNOWN ,  AREB6_01 ,  NFY_01 ,  GTGCCAA_MIR96 ,  S8_01 ,  NFY_Q6 ,  CTTTAAR_UNKNOWN ,  OCT1_06 ,  RORA1_01 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  YTAAYNGCT_UNKNOWN ,  PIT1_Q6 ,  STAT5A_04 ,  IRF7_01 ,  YTAATTAA_LHX3_01 ,  CP2_02 ,  CTGYNNCTYTAA_UNKNOWN ,  TGATTTRY_GFI1_01 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  YAATNANRNNNCAG_UNKNOWN ,  CRX_Q4 ,  ER_Q6 ,  CEBPGAMMA_Q6 ,  IRF2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

4p15.32

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