QuickView for LDOC1;jsessionid=CB48D0EF37462FAC083B95845548EAAC (gene)

Gene Symbol:

LDOC1 Homo sapiens

Full name:

LDOC1, regulator of NFKB signaling

Synonyms:

BCUR1, Mar7, Mart7, RTL7, SIRH7, protein LDOC1, Sushi-Ichi retrotransposon homolog 7, breast cancer, up-regulated 1, leucine zipper down-regulated in cancer 1, leucine zipper downregulated in cancer, leucine zipper protein down-regulated in cancer cells, mammalian retrotransposon-derived 7, retrotransposon Gag like 7

Genomic Location:

Chr X: 140097596-140098976

Description:

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The...

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The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GABP_B ,  FREAC7_01 ,  CTATGCA_MIR153 ,  CTTTGA_LEF1_Q2 ,  CAGGTA_AREB6_01 ,  ELK1_01 ,  CCTGCTG_MIR214 ,  AAGCACT_MIR520F ,  CTTTGT_LEF1_Q2 ,  P300_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-214

miRNA binding sites
(Source: miRecords):

hsa-miR-155 Targeted Genes ,  kshv-miR-K12-11 Targeted Genes

Cytogenetic Map:

Xq27.1

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