QuickView for LEP (gene)
- Gene Symbol:
- LEP
Homo sapiens - Full name:
- leptin
- Synonyms:
- LEPD, OB, OBS, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), obese protein, obese, mouse, homolog of, obesity factor
- Genomic Location:
- Chr 7: 127668567-127684917
- Description:
-
This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
7q32.1
GO Molecular Function
hormone receptor binding | signaling receptor binding | hormone activity | molecular function regulator | peptide hormone receptor binding | protein binding | receptor regulator activity | receptor ligand activity
GO Biological Process
response to extracellular stimulus | adipose tissue development | regulation of blood vessel diameter | regulation of intracellular protein transport | response to nutrient levels | response to cytokine | cell motility | developmental process involved in reproduction | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | regulation of cholesterol transport | positive regulation of apoptotic process | regulation of localization | gonad development | regulation of carbohydrate metabolic process | lipid transport | regulation of programmed cell death | hormone secretion | positive regulation of peptidyl-tyrosine phosphorylation | female gonad development | peptidyl-amino acid modification | glycerol biosynthetic process | establishment of localization | regulation of autophagy | regulation of immune system process | response to hormone | negative regulation of cellular process | positive regulation of developmental process | fatty acid beta-oxidation | negative regulation of RNA biosynthetic process | glucose metabolic process | positive regulation of lymphocyte activation | bone development | regulation of protein import | cell differentiation | bone mineralization | JAK-STAT cascade | nervous system development | cellular response to extracellular stimulus | response to drug | organ growth | generation of precursor metabolites and energy | regulation of leukocyte mediated cytotoxicity | neurogenesis | glucose homeostasis | polyol metabolic process | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | interleukin-6 secretion | regulation of peptide hormone secretion | generation of neurons | response to antibiotic | regulation of lipid transport | blood vessel morphogenesis | regulation of bone remodeling | sterol metabolic process | cellular process | secretion | peptide hormone secretion | negative regulation of glucagon secretion | organic substance catabolic process | lymphocyte differentiation | monocarboxylic acid transport | regulation of glucose import | localization | protein transport | negative regulation of signaling | developmental growth | neuron development | positive regulation of reactive oxygen species metabolic process | central nervous system neuron differentiation | reproductive system development | response to estradiol | female pregnancy | anion transport | immune system development | regulation of digestive system process | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | negative regulation of amino acid transport | macromolecule localization | negative regulation of apoptotic process | negative regulation of secretion | response to hypoxia | regulation of cell cycle | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | prostaglandin transport | regulation of appetite | negative regulation of hormone secretion | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | gamete generation | cellular response to retinoic acid | regulation of angiogenesis | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | cellular response to lipid | leukocyte tethering or rolling | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | catabolic process | organic cyclic compound metabolic process | interleukin-8 production | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | negative regulation of appetite | cellular lipid metabolic process | T cell activation | positive regulation of tumor necrosis factor production | development of primary sexual characteristics | regulation of peptide secretion | glycerol metabolic process | positive regulation of stress-activated protein kinase signaling cascade | regulation of vasculature development | response to stimulus | ovulation | vasculature development | female gamete generation | acid secretion | regulation of cellular protein localization | monocarboxylic acid metabolic process | positive regulation of cold-induced thermogenesis | regulation of peptidyl-tyrosine phosphorylation | regulation of insulin secretion | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of blood vessel size | positive regulation of phosphatidylinositol 3-kinase signaling | carboxylic acid catabolic process | response to stress | positive regulation of JAK-STAT cascade | cellular response to vitamin | positive regulation of cellular protein localization | positive regulation of lymphocyte proliferation | alcohol metabolic process | regulation of cell proliferation | ovulation cycle | tube morphogenesis | regulation of blood circulation | negative regulation of glucose transmembrane transport | response to peptide | positive regulation of cell-cell adhesion | circadian rhythm | development of primary female sexual characteristics | positive regulation of cell activation | reproduction | secretion by cell | response to alcohol | cardiovascular system development | fatty acid catabolic process | rhythmic process | positive regulation of T cell activation | positive regulation of hormone secretion | negative regulation of transport | hormone activity | regulation of protein transport | blood circulation | negative regulation of metabolic process | hemopoiesis | protein modification process | regulation of peptide transport | regulation of cell adhesion | regulation of steroid biosynthetic process | cellular biosynthetic process | ovulation from ovarian follicle | macromolecule modification | regulation of lipid storage | cell-cell signaling | regulation of steroid metabolic process | regulation of TOR signaling | negative regulation of transmembrane transport | activation of protein kinase activity | insulin secretion | regulation of intracellular transport | molecular function regulator | regulation of lipoprotein lipid oxidation | blood vessel development | response to ethanol | leukocyte migration | regulation of nucleic acid-templated transcription | leukocyte differentiation | regulation of cellular response to stress | locomotion | organic hydroxy compound metabolic process | response to nitrogen compound | central nervous system neuron development | cellular response to hormone stimulus | positive regulation of mononuclear cell proliferation | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of secretion by cell | regulation of cartilage development | multicellular organism development | response to activity | cell migration | regulation of intestinal cholesterol absorption | regulation of MAPK cascade | phosphorus metabolic process | response to vitamin E | interleukin-12 production | positive regulation of protein kinase B signaling | regulation of catalytic activity | lipid metabolic process | negative regulation of glucose import | regulation of intestinal absorption | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of nitric-oxide synthase activity | regulation of T cell activation | regulation of gene expression | fatty acid transport | prostaglandin secretion | positive regulation of secretion | organic substance transport | response to lipid | regulation of response to food | regulation of blood pressure | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | digestive system process | regulation of lymphocyte activation | negative regulation of lipid storage | positive regulation of luteinizing hormone secretion | positive regulation of p38MAPK cascade | regulation of protein localization to nucleus | regulation of hepatic stellate cell activation | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | positive regulation of STAT cascade | peptide transport | cytokine-mediated signaling pathway | bone growth | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of transcription by RNA polymerase II | response to nutrient | organic acid transport | cellular response to L-ascorbic acid | activation of protein kinase C activity | intestinal absorption | carbohydrate biosynthetic process | cellular response to cytokine stimulus | interleukin-8 secretion | regulation of cytokine production involved in inflammatory response | cardiac muscle hypertrophy | positive regulation of protein localization to nucleus | biosynthetic process | negative regulation of appetite by leptin-mediated signaling pathway | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | eating behavior | negative regulation of peptide hormone secretion | angiogenesis | organic anion transport | phosphorylation | negative regulation of ion transport | carbohydrate metabolic process | positive regulation of follicle-stimulating hormone secretion | interleukin-6 production | response to toxic substance | leptin-mediated signaling pathway | protein phosphorylation | regulation of tumor necrosis factor production | phosphate-containing compound metabolic process | positive regulation of cellular response to insulin stimulus | negative regulation of autophagy | ovulation cycle process | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of natural killer cell proliferation | cellular lipid catabolic process | positive regulation of tyrosine phosphorylation of STAT protein | regulation of endocrine process | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of TOR signaling | lipid modification | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of tube size | positive regulation of transport | response to retinoic acid | regulation of lipid biosynthetic process | positive regulation of hepatic stellate cell activation | ossification involved in bone maturation | carboxylic acid metabolic process | lymphocyte activation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | bile acid metabolic process | neuron differentiation | multicellular organism reproduction | cytokine production | T cell differentiation | regulation of signaling receptor activity | receptor regulator activity | protein metabolic process | cellular response to nutrient | regulation of establishment of protein localization | negative regulation of response to food | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of innate immune response | regulation of protein import into nucleus | leukocyte adhesion to vascular endothelial cell | regulation of JAK-STAT cascade | regulation of kinase activity | import into cell | adult feeding behavior | regulation of intracellular signal transduction | response to leptin | response to insulin | anatomical structure development | cell surface receptor signaling pathway | regulation of vasoconstriction | regulation of glucose metabolic process | leukocyte cell-cell adhesion | metabolic process | lipid localization | cytokine secretion | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | hexose metabolic process | developmental maturation | cholesterol metabolic process | oxidation-reduction process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of tube diameter | cellular response to carbohydrate stimulus | regulation of tissue remodeling | amide transport | chemical homeostasis | endocytosis | regulation of secretion | behavior | positive regulation of cell death | cell adhesion | receptor ligand activity | hormone transport | lipid catabolic process | regulation of intestinal lipid absorption | organic substance metabolic process | connective tissue development | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of glucose transmembrane transport | animal organ development | positive regulation of ion transport | positive regulation of peroxisome proliferator activated receptor signaling pathway | regulation of endothelial cell proliferation | regulation of insulin receptor signaling pathway | regulation of cell activation | regulation of protein secretion | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | biomineral tissue development | fatty acid metabolic process | response to L-ascorbic acid | establishment of protein localization | cell-cell adhesion | positive regulation of cytokine production | positive regulation of intracellular transport | regulation of brown fat cell differentiation | cell activation | positive regulation of MAPK cascade | lipid oxidation | regulation of natural killer cell mediated cytotoxicity | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | negative regulation of cartilage development | adult behavior | bone maturation | steroid metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of peroxisome proliferator activated receptor signaling pathway | positive regulation of developmental growth | signaling | feeding behavior | positive regulation of growth | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | cell development | energy reserve metabolic process | regulation of developmental growth | regulation of T cell proliferation | protein localization | regulation of epithelial cell proliferation | organic acid metabolic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of follicle-stimulating hormone secretion | carboxylic acid transport | regulation of cytokine production | hormone metabolic process | anatomical structure morphogenesis | positive regulation of protein import into nucleus | regulation of glucagon secretion | reproductive structure development | tyrosine phosphorylation of STAT protein | regulation of developmental process | regulation of ion transport | energy derivation by oxidation of organic compounds | developmental process | positive regulation of protein import | cellular protein modification process | digestion | cellular extravasation | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | response to dietary excess | signal release | response to organonitrogen compound | regulation of gluconeogenesis | regulation of anion transport | fatty acid oxidation | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | regulation of lipoprotein metabolic process | ion transport | positive regulation of fat cell apoptotic process | skeletal system development | immune system process | regulation of natural killer cell mediated immunity | negative regulation of vasoconstriction | cellular metabolic process | hematopoietic or lymphoid organ development | placenta development | female sex differentiation | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | protein secretion | response to carbohydrate | negative regulation of cell death | bone mineralization involved in bone maturation | positive regulation of blood vessel diameter | circulatory system development | regulation of inflammatory response | carbohydrate homeostasis | muscle hypertrophy | positive regulation of nucleocytoplasmic transport | sexual reproduction | phagocytosis | positive regulation of leukocyte cell-cell adhesion | negative regulation of glutamine transport | muscle system process | positive regulation of signaling | signal transduction | cellular response to leptin stimulus | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | regulation of p38MAPK cascade | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
cell | cytoplasm | extracellular region | extracellular space | intracellular
