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QuickView for LFA3 (gene)


Gene Symbol:
CD58 Homo sapiens Homo sapiens
Full name:
CD58 molecule
Synonyms:
LFA-3, LFA3, ag3, lymphocyte function-associated antigen 3, CD58 antigen, (lymphocyte function-associated antigen 3), surface glycoprotein LFA-3
Genomic Location:
Chr 1: 116858680-116915126
Description:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described.
Orthologs:
Macaca mulatta Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1p13.1





GO Molecular Function

signaling receptor binding | protein binding

GO Biological Process

exocytosis | response to cytokine | cell motility | neutrophil activation | regulation of localization | heterotypic cell-cell adhesion | establishment of localization | cellular response to tumor necrosis factor | defense response | positive regulation of protein secretion | cellular process | secretion | leukocyte degranulation | localization | positive regulation of interleukin-8 production | regulation of cellular process | leukocyte activation | cellular response to interferon-gamma | regulation of peptide secretion | response to stimulus | regulation of interleukin-8 secretion | neutrophil degranulation | response to stress | leukocyte activation involved in immune response | secretion by cell | positive regulation of cytokine secretion | regulation of protein transport | regulation of peptide transport | leukocyte migration | positive regulation of peptide secretion | locomotion | cell migration | leukocyte mediated immunity | positive regulation of secretion | vesicle-mediated transport | cellular response to cytokine stimulus | regulated exocytosis | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | positive regulation of establishment of protein localization | positive regulation of transport | regulation of cytokine secretion | regulation of establishment of protein localization | response to organic substance | regulation of secretion | cell adhesion | immune response | positive regulation of interleukin-8 secretion | regulation of protein secretion | cell-cell adhesion | response to interferon-gamma | positive regulation of cytokine production | cell activation | positive regulation of protein transport | regulation of cytokine production | regulation of transport | innate immune response | neutrophil mediated immunity | immune system process | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization

GO Cellular Component

secretory granule | integral component of membrane | organelle membrane | tertiary granule | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | secretory granule membrane | ficolin-1-rich granule membrane | secretory vesicle | endomembrane system | plasma membrane | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | extracellular space | cell periphery | intracellular vesicle | cell surface | intracellular | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane