QuickView for LGI1 (gene)

Gene Symbol:

LGI1 Homo sapiens

Full name:

leucine rich glioma inactivated 1

Synonyms:

ADLTE, ADPAEF, ADPEAF, EPITEMPIN, EPT, ETL1, IB1099, leucine-rich glioma-inactivated protein 1, epitempin-1

Genomic Location:

Chr 10: 95507668-95547906

Description:

This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in ...

View Full Description

This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  RTAAACA_FREAC2_01 ,  OCT1_05 ,  STAT4_01 ,  PR_02 ,  AGCYRWTTC_UNKNOWN ,  ZIC1_01 ,  FOX_Q2 ,  HFH3_01 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  AAAYWAACM_HFH4_01 ,  CTTTGCA_MIR527 ,  HFH1_01 ,  MEF2_04 ,  WGTTNNNNNAAA_UNKNOWN ,  SRY_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GR_Q6_01 ,  EGR2_01 ,  COMP1_01 ,  TATAAA_TATA_01 ,  CACCCBINDINGFACTOR_Q6 ,  GGATTA_PITX2_Q2 ,  FREAC3_01 ,  TTCYRGAA_UNKNOWN ,  HNF3_Q6 ,  EVI1_05 ,  RRAGTTGT_UNKNOWN ,  FOXJ2_01 ,  NKX61_01 ,  IRF_Q6 ,  GCM_Q2 ,  HSF_Q6 ,  OCT1_06 ,  HAND1E47_01 ,  POU3F2_02 ,  GR_01 ,  TEF_Q6 ,  SMAD4_Q6 ,  ICSBP_Q6 ,  TBP_01 ,  CAGCTG_AP4_Q5 ,  CTGTTAC_MIR194 ,  CAATGCA_MIR33 ,  STTTCRNTTT_IRF_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

10q23.33

search → result