QuickView for LIN28A;jsessionid=266D2CAFC60AFA786D419B296693A045 (gene)

Gene Symbol:

LIN28A Homo sapiens

Full name:

lin-28 homolog A

Synonyms:

CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, protein lin-28 homolog A, RNA-binding protein LIN-28, zinc finger CCHC domain-containing protein 1, zinc finger, CCHC domain containing 1

Genomic Location:

Chr 1: 26609856-26628806

Description:

This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This p...

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This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  TGIF_01 ,  GTGTTGA_MIR505 ,  MAZR_01 ,  DR3_Q4 ,  GATA1_01 ,  STAT1_02 ,  MAZ_Q6 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  VDR_Q3 ,  MYC_Q2 ,  SYATTGTG_UNKNOWN ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  SMAD3_Q6 ,  CATTGTYY_SOX9_B1 ,  NFY_C ,  MAX_01 ,  PEA3_Q6 ,  LXR_DR4_Q3 ,  TEL2_Q6 ,  TTTGTAG_MIR520D ,  AP2GAMMA_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TCTGATC_MIR383 ,  FXR_IR1_Q6 ,  AMEF2_Q6 ,  SREBP1_Q6 ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  TTTNNANAGCYR_UNKNOWN ,  AP2ALPHA_01 ,  MAF_Q6 ,  GATA1_04 ,  MYAATNNNNNNNGGC_UNKNOWN ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  CDPCR3HD_01 ,  TFIII_Q6 ,  MYCMAX_02 ,  TAL1BETAE47_01 ,  LEF1_Q2 ,  GCACCTT_MIR18A_MIR18B ,  GGATTA_PITX2_Q2 ,  TEF1_Q6 ,  LFA1_Q6 ,  RREB1_01 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  AP4_01 ,  PXR_Q2 ,  TST1_01 ,  SP3_Q3 ,  ZID_01 ,  MYOD_Q6 ,  ATTCTTT_MIR186 ,  ACTACCT_MIR196A_MIR196B ,  MYCMAX_01 ,  ACCAAAG_MIR9 ,  CDPCR1_01 ,  AREB6_01 ,  PITX2_Q2 ,  USF_C ,  CCCNNGGGAR_OLF1_01 ,  MGGAAGTG_GABP_B ,  CTTTAAR_UNKNOWN ,  ACTGCAG_MIR173P ,  TGCCAAR_NF1_Q6 ,  POU1F1_Q6 ,  MEIS1_01 ,  TAXCREB_02 ,  CAGCAGG_MIR370 ,  PTF1BETA_Q6 ,  STAT_01 ,  NMYC_01 ,  CETS1P54_01 ,  USF_Q6_01 ,  TAATTA_CHX10_01 ,  WGGAATGY_TEF1_Q6 ,  SCGGAAGY_ELK1_02 ,  NRF2_01 ,  CTGYNNCTYTAA_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  TAL1BETAITF2_01 ,  TGACAGNY_MEIS1_01 ,  STAT1_01 ,  STAT5A_01 ,  CACBINDINGPROTEIN_Q6 ,  SMAD_Q6 ,  USF2_Q6 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  PAX4_03 ,  CRX_Q4 ,  DR4_Q2 ,  USF_02 ,  NFKB_C ,  PAX4_01 ,  SRF_C ,  CP2_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-378

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miRNA binding sites
(Source: miRecords):

hsa-let-7a Targeted Genes ,  hsa-miR-125a-5p Targeted Genes ,  hsa-let-7b Targeted Genes ,  hsa-miR-125b Targeted Genes

Cytogenetic Map:

1p36.11

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