QuickView for LMAN1;jsessionid=C231F3B169C429ACE63EE94620169768 (gene)

Gene Symbol:

LMAN1 Homo sapiens

Full name:

lectin, mannose binding 1

Synonyms:

ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58, protein ERGIC-53, ER-Golgi intermediate compartment 53 kDa protein, endoplasmic reticulum-golgi intermediate compartment protein 53, intracellular mannose-specific lectin MR60

Genomic Location:

Chr 18: 55148088-55177463

Description:

The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recogn...

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The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  EGR_Q6 ,  GGGCGGR_SP1_Q6 ,  CCAATNNSNNNGCG_UNKNOWN ,  TCF11_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-140

Cytogenetic Map:

18q21.32

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