QuickView for LMX1A;jsessionid=A189F7041CC56322FC54BFF72171742C (gene)
- Gene Symbol:
- LMX1A
Homo sapiens - Full name:
- LIM homeobox transcription factor 1 alpha
- Synonyms:
- LMX1, LMX1.1, LIM homeobox transcription factor 1-alpha, LIM/homeobox protein 1.1
- Genomic Location:
- Chr 1: 163437729-163591641
- Description:
-
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developin...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Canis lupus familiaris , Pan troglodytes , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
1q23.3
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | brain development | cell morphogenesis | positive regulation of macromolecule biosynthetic process | chemosensory behavior | regulation of neurogenesis | neuron projection morphogenesis | regulation of cell development | hippocampus development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cell differentiation | nervous system development | cell part morphogenesis | neurogenesis | generation of neurons | positive regulation of cellular biosynthetic process | cellular process | cell projection morphogenesis | neuron development | central nervous system neuron differentiation | axon guidance | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | head development | response to stimulus | cell morphogenesis involved in neuron differentiation | metencephalon development | neuron projection guidance | cellular nitrogen compound biosynthetic process | midbrain development | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | locomotion | system development | nitrogen compound metabolic process | multicellular organism development | learning or memory | cerebellum development | telencephalon development | regulation of neuron differentiation | regulation of gene expression | axon development | nervous system process | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | synapse organization | axonogenesis | cognition | olfactory behavior | biosynthetic process | locomotory behavior | aromatic compound biosynthetic process | hindbrain development | cell morphogenesis involved in differentiation | regulation of cellular metabolic process | dentate gyrus development | limbic system development | regulation of RNA metabolic process | neuron differentiation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of growth | anatomical structure development | cell projection organization | metabolic process | regulation of RNA biosynthetic process | behavior | midbrain dopaminergic neuron differentiation | nucleobase-containing compound metabolic process | neuron projection development | organic substance metabolic process | animal organ development | forebrain development | negative regulation of neuron differentiation | pallium development | gene expression | transcription, DNA-templated | dopaminergic neuron differentiation | memory | regulation of transcription, DNA-templated | cell development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of nervous system development | regulation of developmental process | developmental process | regulation of cell growth | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | cellular metabolic process | negative regulation of cell development | chemotaxis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
