QuickView for LONP2;jsessionid=583065620E0EA563108DD8AC19DC7E21 (gene)

Gene Symbol:

LONP2 Homo sapiens

Full name:

lon peptidase 2, peroxisomal

Synonyms:

LONP, LONPL, PLON, PSLON, lon protease homolog 2, peroxisomal, lon protease 2, lon protease-like protein 2, peroxisomal LON protease like, peroxisomal Lon protease homolog 2

Genomic Location:

Chr 16: 46835712-46944908

Description:

In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxida...

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In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

16q12.1

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