QuickView for LPP3 (gene)

Gene Symbol:

PLPP3 Homo sapiens

Full name:

phospholipid phosphatase 3

Synonyms:

Dri42, LPP3, PAP2B, PPAP2B, VCIP, phospholipid phosphatase 3, PAP2 beta, lipid phosphate phosphohydrolase 3, phosphatidate phosphohydrolase type 2b, phosphatidic acid phosphatase type 2B, type-2 phosphatidic acid phosphatase-beta, vascular endothelial growth factor and type I collagen inducible

Genomic Location:

Chr 1: 56733021-56817845

Description:

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma me...

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The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  PAX4_04 ,  SRF_Q6 ,  AAAYWAACM_HFH4_01 ,  GTGACTT_MIR224 ,  EVI1_04 ,  WGTTNNNNNAAA_UNKNOWN ,  SRY_01 ,  TAL1BETAE47_01 ,  PAX4_02 ,  CATTTCA_MIR203 ,  YYCATTCAWW_UNKNOWN ,  RP58_01 ,  GTAAGAT_MIR200A ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  S8_01 ,  NKX25_02 ,  FREAC2_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IK2_01 ,  WWTAAGGC_UNKNOWN ,  GAGCCAG_MIR149 ,  IK3_01 ,  IK1_01 ,  SRF_Q5_01 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  PAX4_03 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-410

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Cytogenetic Map:

1p32.2

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