QuickView for LRP8;jsessionid=30CDE4AC1253CFE4D86FD120B5ADCF7A (gene)

Gene Symbol:

LRP8 Homo sapiens

Full name:

LDL receptor related protein 8

Synonyms:

APOER2, HSZ75190, LRP-8, MCI1, low-density lipoprotein receptor-related protein 8, ApoE receptor 2, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Genomic Location:

Chr 1: 53483800-53566409

Description:

This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during develo...

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This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  ZIC1_01 ,  MYC_Q2 ,  CACGTG_MYC_Q2 ,  ZF5_01 ,  TTCNRGNNNNTTC_HSF_Q6 ,  NFY_C ,  YATTNATC_UNKNOWN ,  AP2GAMMA_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ZIC3_01 ,  SREBP1_Q6 ,  CTTTGA_LEF1_Q2 ,  AP2ALPHA_01 ,  MYCMAX_B ,  WTGAAAT_UNKNOWN ,  LEF1_Q6 ,  LEF1_Q2 ,  GTGACGY_E4F1_Q6 ,  YYCATTCAWW_UNKNOWN ,  NFY_Q6_01 ,  LFA1_Q6 ,  ALPHACP1_01 ,  MYCMAX_01 ,  USF_C ,  NFY_01 ,  CCCNNGGGAR_OLF1_01 ,  HIF1_Q5 ,  E2F1_Q3_01 ,  NFY_Q6 ,  SREBP_Q3 ,  ZIC2_01 ,  TGCTTTG_MIR330 ,  E2F_Q2 ,  CTTTGT_LEF1_Q2 ,  PAX3_B ,  USF2_Q6 ,  AGGCACT_MIR5153P ,  AACTTT_UNKNOWN ,  HIF1_Q3 ,  ETF_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-330

Cytogenetic Map:

1p32.3

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