QuickView for LYN;jsessionid=2D4B9F9A381C016BED2A8508D9B88157 (gene)
- Gene Symbol:
- LYN
Homo sapiens - Full name:
- LYN proto-oncogene, Src family tyrosine kinase
- Synonyms:
- JTK8, p53Lyn, p56Lyn, tyrosine-protein kinase Lyn, lck/Yes-related novel protein tyrosine kinase, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
- Genomic Location:
- Chr 8: 56954926-57085685
- Description:
-
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_05 , PU1_Q6 , OCT1_B , ETS_Q4 , RYTTCCTG_ETS2_B , OCT1_01 , YATGNWAAT_OCT_C , OCT_Q6 , YTATTTTNR_MEF2_02 , TEL2_Q6
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
8q12.1
GO Molecular Function
ephrin receptor binding | platelet-derived growth factor receptor binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | lipid binding | SH3 domain binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | catalytic activity | phosphorylation-dependent protein binding | ion channel binding | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | modification-dependent protein binding | glycolipid binding | purine nucleotide binding | sphingolipid binding | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein tyrosine kinase activity | protein binding | glycosphingolipid binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | growth factor receptor binding | drug binding | gamma-tubulin binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | leukocyte homeostasis | negative regulation of leukocyte activation | response to extracellular stimulus | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | lysosome localization | negative regulation of phosphorylation | adaptive immune response | positive regulation of amyloid precursor protein catabolic process | positive regulation of locomotion | negative regulation of MAPK cascade | negative regulation of immune system process | exocytosis | positive regulation of cellular component organization | regulation of B cell activation | cell motility | regulation of neurogenesis | immune response-regulating signaling pathway | response to lipopolysaccharide | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | hormone secretion | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | erythrocyte homeostasis | Fc receptor mediated inhibitory signaling pathway | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | myeloid cell differentiation | platelet degranulation | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | JAK-STAT cascade | defense response | nervous system development | cellular response to extracellular stimulus | response to growth hormone | negative regulation of B cell proliferation | response to drug | lymphocyte costimulation | negative regulation of protein phosphorylation | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular component movement | generation of neurons | negative regulation of toll-like receptor 4 signaling pathway | innate immune response activating cell surface receptor signaling pathway | intracellular transport | regulation of toll-like receptor 4 signaling pathway | positive regulation of phosphatidylinositol 3-kinase activity | histamine secretion | positive regulation of dendritic cell apoptotic process | innate immune response-activating signal transduction | cellular process | production of molecular mediator involved in inflammatory response | secretion | Fc-gamma receptor signaling pathway involved in phagocytosis | leukocyte degranulation | establishment of organelle localization | regulation of cell motility | localization | protein transport | negative regulation of signaling | positive regulation of immune effector process | neuron development | regulation of platelet aggregation | tolerance induction | immune system development | azole transport | macromolecule localization | hemostasis | regulation of chemotaxis | regulation of proteolysis | regulation of monocyte chemotaxis | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | cellular response to growth hormone stimulus | establishment of localization in cell | negative regulation of cellular metabolic process | response to peptide hormone | regulation of myeloid leukocyte differentiation | mast cell activation | regulation of cell differentiation | interspecies interaction between organisms | histamine transport | cellular response to retinoic acid | regulation of lymphocyte apoptotic process | regulation of platelet activation | peptidyl-tyrosine autophosphorylation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | organelle localization | negative regulation of mononuclear cell proliferation | cellular response to molecule of bacterial origin | tolerance induction to self antigen | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | ephrin receptor signaling pathway | cellular component organization | regulation of mast cell degranulation | negative regulation of toll-like receptor signaling pathway | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of antigen receptor-mediated signaling pathway | regulation of Fc receptor mediated stimulatory signaling pathway | positive regulation of innate immune response | regulation of peptidyl-tyrosine phosphorylation | oligodendrocyte development | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | regulation of oligodendrocyte progenitor proliferation | response to sterol depletion | response to stress | positive regulation of JAK-STAT cascade | negative regulation of lymphocyte activation | leukocyte activation involved in immune response | negative regulation of protein kinase activity | regulation of cell proliferation | response to peptide | positive regulation of cell-cell adhesion | positive regulation of cell activation | activation of innate immune response | cellular localization | secretion by cell | response to temperature stimulus | positive regulation of proteolysis | response to molecule of bacterial origin | positive regulation of T cell activation | immune response-activating signal transduction | positive regulation of gliogenesis | regulation of protein transport | negative regulation of metabolic process | hemopoiesis | regulation of wound healing | negative regulation of hemopoiesis | protein modification process | regulation of peptide transport | regulation of cell adhesion | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | cell-cell signaling | negative regulation of toll-like receptor 2 signaling pathway | negative regulation of ERK1 and ERK2 cascade | B cell receptor signaling pathway | regulation of intracellular transport | myeloid cell homeostasis | leukocyte migration | blood coagulation | leukocyte differentiation | regulation of cellular response to stress | locomotion | response to nitrogen compound | regulation of calcium ion transport into cytosol | cellular response to hormone stimulus | positive regulation of Fc receptor mediated stimulatory signaling pathway | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of toll-like receptor signaling pathway | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | response to amino acid | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | cellular response to DNA damage stimulus | leukocyte mediated immunity | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | wound healing | Fc-gamma receptor signaling pathway | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process | regulation of T cell activation | regulation of neuron differentiation | platelet activation | organic substance transport | cellular response to stress | response to lipid | cellular response to peptide | mast cell degranulation | cellular response to heat | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | response to axon injury | negative regulation of myeloid cell differentiation | regulation of blood coagulation | mast cell mediated immunity | regulation of mast cell activation | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | positive regulation of STAT cascade | peptide transport | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | vesicle-mediated transport | regulation of cellular component movement | B cell homeostasis | positive regulation of hydrolase activity | Fc-epsilon receptor signaling pathway | positive regulation of cell differentiation | regulation of release of sequestered calcium ion into cytosol | homeostasis of number of cells | positive regulation of cell migration | positive regulation of mast cell proliferation | regulation of cellular protein metabolic process | negative regulation of immune response | glial cell differentiation | regulation of cell adhesion mediated by integrin | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | regulated exocytosis | positive regulation of endopeptidase activity | regulation of calcium ion transmembrane transport | JAK-STAT cascade involved in growth hormone signaling pathway | response to toxic substance | positive regulation of leukocyte apoptotic process | protein phosphorylation | regulation of amyloid precursor protein catabolic process | regulation of leukocyte migration | phosphate-containing compound metabolic process | regulation of B cell apoptotic process | response to bacterium | regulation of lipid kinase activity | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of tyrosine phosphorylation of STAT protein | lymphocyte homeostasis | negative regulation of cell activation | regulation of glial cell proliferation | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | negative regulation of MAP kinase activity | lipopolysaccharide-mediated signaling pathway | response to retinoic acid | regulation of phospholipid metabolic process | viral process | coagulation | negative regulation of B cell activation | protein tyrosine kinase activity | positive regulation of glial cell proliferation | positive regulation of molecular function | regulation of cytokine secretion | neuron differentiation | cytokine production | activation of immune response | protein metabolic process | regulation of establishment of protein localization | immune response-inhibiting signal transduction | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of homotypic cell-cell adhesion | regulation of hemopoiesis | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of exocytosis | response to insulin | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | positive regulation of cell development | cytokine secretion | dendritic cell differentiation | negative regulation of leukocyte proliferation | positive regulation of leukocyte activation | regulation of body fluid levels | regulation of erythrocyte differentiation | oligodendrocyte differentiation | amide transport | regulation of vesicle-mediated transport | endocytosis | regulation of secretion | positive regulation of cell death | immune response | hormone transport | protein kinase activity | neuron projection development | organic substance metabolic process | regulation of sequestering of calcium ion | animal organ development | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | positive regulation of programmed cell death | positive regulation of kinase activity | response to heat | regulation of phosphate metabolic process | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | establishment of protein localization | negative regulation of mast cell proliferation | regulation of regulated secretory pathway | cell activation | negative regulation of protein metabolic process | T cell costimulation | regulation of response to wounding | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | signaling | immune response-inhibiting cell surface receptor signaling pathway | positive regulation of oligodendrocyte progenitor proliferation | glial cell development | response to organic cyclic compound | cell development | growth hormone receptor signaling pathway | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | regulation of endopeptidase activity | cation transport | response to biotic stimulus | ammonium transport | regulation of nervous system development | regulation of developmental process | regulation of ion transport | positive regulation of neural precursor cell proliferation | kinase activity | developmental process | erythrocyte differentiation | positive regulation of B cell receptor signaling pathway | Fc receptor signaling pathway | regulation of calcium ion transport | cellular protein modification process | Fc receptor mediated stimulatory signaling pathway | regulation of transport | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of cell-cell adhesion | neurotransmitter transport | signal release | positive regulation of lipid kinase activity | response to organonitrogen compound | stimulatory C-type lectin receptor signaling pathway | regulation of B cell receptor signaling pathway | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of neuron differentiation | positive regulation of lipid metabolic process | ion transport | regulation of cell projection organization | negative regulation of lymphocyte proliferation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | regulation of cell death | protein secretion | positive regulation of cell motility | response to carbohydrate | regulation of inflammatory response | phagocytosis | positive regulation of leukocyte cell-cell adhesion | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | histamine secretion by mast cell | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | mitochondrial intermembrane space | cytoplasmic side of plasma membrane | organelle inner membrane | intracellular membrane-bounded organelle | synapse | mitochondrial inner membrane | extrinsic component of membrane | adherens junction | organelle membrane | cell | cytoplasmic side of membrane | mast cell granule | plasma membrane protein complex | extrinsic component of plasma membrane | intrinsic component of membrane | integrin complex | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | cell-cell adherens junction | mitochondrial crista | integrin alpha2-beta1 complex | cell-cell junction | Golgi apparatus | protein-containing complex | endomembrane system | postsynapse | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | membrane raft | vacuole | vesicle | perinuclear region of cytoplasm | postsynaptic density | extracellular exosome | asymmetric synapse | mitochondrion | lytic vacuole | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | postsynaptic specialization | mitochondrial envelope | lysosome | extracellular space | cell periphery | membrane-enclosed lumen | protein complex involved in cell adhesion | mitochondrial membrane | cytosol | intracellular | cell junction | membrane | intrinsic component of plasma membrane
