QuickView for LYST (gene)

Gene Symbol:

LYST Homo sapiens

Full name:

lysosomal trafficking regulator

Synonyms:

CHS, CHS1, lysosomal-trafficking regulator, Chediak-Higashi syndrome 1, beige homolog

Genomic Location:

Chr 1: 233890966-234096843

Description:

This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has n...

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This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  AACATTC_MIR4093P ,  ATATGCA_MIR448 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

1q42.3

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