QuickView for Lime (gene)
- Gene Symbol:
- LIME1
Homo sapiens - Full name:
- Lck interacting transmembrane adaptor 1
- Synonyms:
- LIME, dJ583P15.4, lck-interacting transmembrane adapter 1, lck-interacting membrane protein, lck-interacting molecule
- Genomic Location:
- Chr 20: 61838422-61840904
- Description:
-
This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
20q13.33
GO Molecular Function
kinase binding | protein kinase binding | enzyme binding | protein binding
GO Biological Process
positive regulation of immune response | adaptive immune response | immune response-regulating signaling pathway | regulation of cellular localization | regulation of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | regulation of MAP kinase activity | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | cellular process | regulation of immune response | regulation of cellular process | regulation of metabolic process | response to stimulus | positive regulation of immune system process | immune response-activating signal transduction | B cell receptor signaling pathway | regulation of nucleic acid-templated transcription | regulation of calcium ion transport into cytosol | regulation of signal transduction | regulation of MAPK cascade | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | regulation of release of sequestered calcium ion into cytosol | regulation of cellular protein metabolic process | regulation of calcium ion transmembrane transport | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of RNA metabolic process | activation of immune response | regulation of kinase activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | regulation of RNA biosynthetic process | immune response | regulation of sequestering of calcium ion | regulation of phosphate metabolic process | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of ion transport | regulation of calcium ion transport | regulation of transport | immune system process | regulation of I-kappaB kinase/NF-kappaB signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | plasma membrane protein complex | intrinsic component of membrane | receptor complex | protein-containing complex | plasma membrane | extracellular region | extracellular space | cell periphery | B cell receptor complex | membrane
