QuickView for MAP2K1;jsessionid=9DC9B346C0F50C660A8D206DF8DD93F0 (gene)

Gene Symbol:

MAP2K1 Homo sapiens

Full name:

mitogen-activated protein kinase kinase 1

Synonyms:

CFC3, MAPKK1, MEK1, MKK1, PRKMK1, dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK 1, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)

Genomic Location:

Chr 15: 64466679-64570936

Description:

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimul...

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The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  TTANTCA_UNKNOWN ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CTACTGT_MIR199A ,  TTF1_Q6 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  AP1FJ_Q2 ,  GTGCCAA_MIR96 ,  NRF2_Q4 ,  AP1_Q4 ,  RGAGGAARY_PU1_Q6 ,  TGCTTTG_MIR330 ,  AAAGGAT_MIR501 ,  GGCAGTG_MIR3243P ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TGASTMAGC_NFE2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-96

Cytogenetic Map:

15q22.31

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