QuickView for MAP2K5;jsessionid=1F2F066480FE0B243AC75627AD3BB682 (gene)
- Gene Symbol:
- MAP2K5
Homo sapiens - Full name:
- mitogen-activated protein kinase kinase 5
- Synonyms:
- HsT17454, MAPKK5, MEK5, PRKMK5, dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAP kinase kinase MEK5b, MAPK/ERK kinase 5, MAPKK 5, MEK 5
- Genomic Location:
- Chr 15: 65622075-65886506
- Description:
-
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this ki...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
NKX25_01 , TGIF_01 , TCANNTGAY_SREBP1_01 , FOX_Q2 , RSRFC4_01 , HFH3_01 , GATA_C , YTATTTTNR_MEF2_02 , EVI1_04 , RSRFC4_Q2
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
15q23
| Transcripts Names |
|---|
| NM_002757 |
| NM_145160 |
| NM_001206804 |
| NM_145161 |
| NM_145162 |
| XM_011521787 |
| XM_024449988 |
| XM_017022414 |
| XR_001751355 |
| XM_011521788 |
GO Molecular Function
cation binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | MAP kinase kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | intracellular signal transduction | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of cysteine-type endopeptidase activity | ERK5 cascade | negative regulation of cellular process | regulation of MAP kinase activity | negative regulation of cell migration involved in sprouting angiogenesis | negative regulation of RNA biosynthetic process | positive regulation of epithelial cell proliferation | regulation of sprouting angiogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | negative regulation of proteolysis | positive regulation of cellular biosynthetic process | cellular process | negative regulation of chemokine (C-X-C motif) ligand 2 production | regulation of cytokine biosynthetic process | regulation of cell motility | negative regulation of signaling | regulation of embryonic development | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | negative regulation of apoptotic process | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | MAPK cascade | regulation of vasculature development | response to stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | response to stress | regulation of heterotypic cell-cell adhesion | regulation of cell proliferation | negative regulation of angiogenesis | response to laminar fluid shear stress | regulation of chemokine (C-X-C motif) ligand 2 production | protein serine/threonine kinase activity | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of cell adhesion | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | negative regulation of NF-kappaB transcription factor activity | system development | nitrogen compound metabolic process | regulation of signal transduction | regulation of interleukin-8 biosynthetic process | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of peptidase activity | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | negative regulation of chemokine production | cellular response to stress | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | cellular response to fluid shear stress | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of cell migration involved in sprouting angiogenesis | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of heterotypic cell-cell adhesion | regulation of endothelial cell migration | negative regulation of extrinsic apoptotic signaling pathway | negative regulation of epithelial cell migration | regulation of cellular protein metabolic process | phosphorylation | regulation of apoptotic signaling pathway | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of cytokine biosynthetic process | negative regulation of blood vessel endothelial cell migration | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | negative regulation of sprouting angiogenesis | protein tyrosine kinase activity | positive regulation of molecular function | activation of MAPK activity | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of kinase activity | MAP kinase kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | negative regulation of response to cytokine stimulus | metabolic process | negative regulation of interleukin-8 biosynthetic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of cell-cell adhesion involved in gastrulation | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | positive regulation of kinase activity | regulation of phosphate metabolic process | negative regulation of interleukin-8 production | positive regulation of MAPK cascade | negative regulation of protein metabolic process | regulation of epithelial cell migration | response to fluid shear stress | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | negative regulation of signal transduction | signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | regulation of endopeptidase activity | positive regulation of MAP kinase activity | protein serine/threonine/tyrosine kinase activity | regulation of developmental process | kinase activity | developmental process | regulation of cell growth | cellular protein modification process | regulation of chemokine production | negative regulation of transcription by RNA polymerase II | regulation of gastrulation | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | positive regulation of transcription by RNA polymerase II | negative regulation of hydrolase activity | cellular response to laminar fluid shear stress | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | circulatory system development | negative regulation of locomotion | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | spindle | intracellular organelle | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | cytosol | cytoskeleton | intracellular
