QuickView for MAP2K6;jsessionid=308D852F320FF8E9706FCF7472C8518B (gene)

Gene Symbol:

MAP2K6 Homo sapiens

Full name:

mitogen-activated protein kinase kinase 6

Synonyms:

MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, dual specificity mitogen-activated protein kinase kinase 6, MAPK/ERK kinase 6, MAPKK 6, MEK 6, SAPK kinase 3, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6), stress-activated protein kinase kinase 3

Genomic Location:

Chr 17: 64922433-65050065

Description:

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to ...

View Full Description

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  OCT1_05 ,  CEBPA_01 ,  OCT1_B ,  RYTTCCTG_ETS2_B ,  ARNT_01 ,  OCT1_04 ,  AREB6_02 ,  OCT1_01 ,  OCT_Q6 ,  SRF_Q6 ,  E4BP4_01 ,  CEBP_Q2_01 ,  HP1SITEFACTOR_Q6 ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  OCT1_Q5_01 ,  TTAYRTAA_E4BP4_01 ,  OCT_C ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  OCT1_Q6 ,  LEF1_Q6 ,  GGATTA_PITX2_Q2 ,  TNCATNTCCYR_UNKNOWN ,  TGCGCANK_UNKNOWN ,  HNF4_Q6 ,  CREBP1_01 ,  CEBPB_02 ,  SRF_Q4 ,  NERF_Q2 ,  ACTAYRNNNCCCR_UNKNOWN ,  STAT_01 ,  HMGIY_Q6 ,  HLF_01 ,  CEBP_Q3 ,  ELK1_01 ,  TTGTTT_FOXO4_01 ,  ATATGCA_MIR448 ,  CHOP_01 ,  CEBP_C ,  IK2_01 ,  RTTTNNNYTGGM_UNKNOWN ,  IRF7_01 ,  CTGCAGY_UNKNOWN ,  PAX_Q6 ,  SRF_Q5_01 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  FOXM1_01 ,  GCTNWTTGK_UNKNOWN ,  AACTTT_UNKNOWN ,  TATTATA_MIR374

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-374

Cytogenetic Map:

17q24.3

search → result