QuickView for MAP3K4;jsessionid=377DCE537D9D8C5FDE19251AA59471FB (gene)

Gene Symbol:

MAP3K4 Homo sapiens

Full name:

mitogen-activated protein kinase kinase kinase 4

Synonyms:

MAPKKK4, MEKK 4, MEKK4, MTK1, PRO0412, mitogen-activated protein kinase kinase kinase 4, MAP three kinase 1, MAP/ERK kinase kinase 4, MAPK/ERK kinase kinase 4, MEK kinase 4, SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of, dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4), predicted protein of HQ0412

Genomic Location:

Chr 6: 161332812-161458407

Description:

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are acti...

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The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGCCAT_MIR183 ,  CTACTGT_MIR199A ,  NGFIC_01 ,  AAANWWTGC_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  GCCATNTTG_YY1_Q6 ,  YY1_Q6 ,  CAGGTG_E12_Q6 ,  YY1_02 ,  CTGCAGY_UNKNOWN ,  EGR1_01 ,  P300_01 ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

6q26

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