QuickView for MAPK1 (gene)
- Gene Symbol:
- MAPK1
Homo sapiens - Full name:
- mitogen-activated protein kinase 1
- Synonyms:
- ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, mitogen-activated protein kinase 1, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 2, extracellular signal-regulated kinase 2, mitogen-activated protein kinase 2, protein tyrosine kinase ERK2
- Genomic Location:
- Chr 22: 20443946-20551970
- Description:
-
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
22q11.22
GO Molecular Function
protein phosphorylated amino acid binding | kinase binding | protein kinase binding | enzyme binding | nucleic acid binding | phosphotyrosine residue binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | identical protein binding | MAP kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | mitogen-activated protein kinase kinase kinase binding | protein binding | transcription factor binding | MAP kinase kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding
GO Biological Process
cytosine metabolic process | positive regulation of immune response | RNA metabolic process | response to extracellular stimulus | regulation of telomere maintenance via telomerase | cell morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of intracellular protein transport | response to nutrient levels | exocytosis | response to cytokine | positive regulation of cellular component organization | neuron projection morphogenesis | immune response-regulating signaling pathway | neutrophil activation | response to lipopolysaccharide | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | regulation of localization | positive regulation of telomere capping | peptidyl-amino acid modification | positive regulation of peptidyl-threonine phosphorylation | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to dopamine | negative regulation of cellular process | regulation of MAP kinase activity | response to metal ion | cellular response to tumor necrosis factor | regulation of protein import | cell differentiation | immune response-activating cell surface receptor signaling pathway | respiratory tube development | T cell receptor signaling pathway | nervous system development | cellular response to extracellular stimulus | response to drug | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | mesenchyme development | positive regulation of cellular biosynthetic process | cellular process | secretion | Fc-gamma receptor signaling pathway involved in phagocytosis | diadenosine tetraphosphate biosynthetic process | response to exogenous dsRNA | cellular response to granulocyte macrophage colony-stimulating factor stimulus | leukocyte degranulation | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | diadenosine polyphosphate metabolic process | positive regulation of synaptic transmission | nucleotide metabolic process | chemical synaptic transmission | neuron development | reproductive system development | immune system development | positive regulation of telomerase activity | positive regulation of protein kinase activity | hemostasis | axon guidance | cellular response to starvation | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | tissue development | regulation of cell differentiation | interspecies interaction between organisms | caveolin-mediated endocytosis | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | gliogenesis | cellular response to molecule of bacterial origin | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | MAPK cascade | cellular response to metal ion | head development | regulation of telomere capping | thyroid gland development | response to stimulus | peptidyl-threonine phosphorylation | thymus development | outer ear morphogenesis | vasculature development | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | mesenchymal cell development | neutrophil degranulation | respiratory system development | cellular response to fibroblast growth factor stimulus | regulation of cellular response to heat | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | cardiac neural crest cell development involved in heart development | response to stress | neuron projection guidance | leukocyte activation involved in immune response | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | response to starvation | protein serine/threonine kinase activity | programmed cell death | reproduction | cellular response to inorganic substance | secretion by cell | cardiovascular system development | cellular response to cadmium ion | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | immune response-activating signal transduction | cellular response to organic cyclic compound | ERBB signaling pathway | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | RNA polymerase II CTD heptapeptide repeat kinase activity | regulation of peptide transport | modulation of chemical synaptic transmission | cellular biosynthetic process | embryo development | macromolecule modification | cell-cell signaling | trachea morphogenesis | B cell receptor signaling pathway | activation of protein kinase activity | positive regulation of telomere maintenance via telomere lengthening | regulation of intracellular transport | nucleotide biosynthetic process | embryonic placenta development | blood vessel development | stress-activated protein kinase signaling cascade | blood coagulation | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | response to nitrogen compound | apoptotic process | response to nicotine | response to external biotic stimulus | system development | cellular response to nutrient levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | response to granulocyte macrophage colony-stimulating factor | learning or memory | response to dsRNA | mammary gland development | cellular response to DNA damage stimulus | regulation of telomere maintenance | leukocyte mediated immunity | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | cellular response to oxidative stress | regulation of phosphorylation | fibroblast growth factor receptor signaling pathway | regulation of ossification | wound healing | Fc-gamma receptor signaling pathway | positive regulation of chromosome organization | cellular response to amino acid starvation | cellular response to ammonium ion | regulation of gene expression | platelet activation | axon development | cellular response to stress | response to lipid | nervous system process | cell cycle | synaptic signaling | positive regulation of intracellular protein transport | organophosphate metabolic process | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of telomerase activity | cellular ion homeostasis | animal organ morphogenesis | response to ammonium ion | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | placenta blood vessel development | regulation of cell migration | enzyme linked receptor protein signaling pathway | small molecule metabolic process | positive regulation of intracellular signal transduction | cardiocyte differentiation | vesicle-mediated transport | regulation of cellular component movement | response to oxidative stress | axonogenesis | Fc-epsilon receptor signaling pathway | nucleobase-containing small molecule metabolic process | cognition | stem cell differentiation | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | positive regulation of protein localization to nucleus | biosynthetic process | response to cadmium ion | labyrinthine layer development | stress-activated MAPK cascade | sensory perception of pain | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | MAP kinase activity | glial cell differentiation | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | regulated exocytosis | mammary gland epithelial cell proliferation | response to toxic substance | positive regulation of telomere maintenance via telomerase | labyrinthine layer blood vessel development | endocrine system development | protein phosphorylation | cell morphogenesis involved in differentiation | cation homeostasis | phosphate-containing compound metabolic process | sensory organ development | trachea formation | cellular response to drug | regulation of telomere maintenance via telomere lengthening | response to bacterium | response to estrogen | chordate embryonic development | animal organ formation | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of DNA biosynthetic process | response to catecholamine | astrocyte differentiation | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | heart development | homeostatic process | positive regulation of cell proliferation | regulation of Golgi inheritance | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of transport | viral process | coagulation | embryonic morphogenesis | positive regulation of molecular function | regulation of nucleocytoplasmic transport | neuron differentiation | activation of MAPK activity | embryonic organ morphogenesis | response to monoamine | activation of immune response | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | gland development | regulation of protein import into nucleus | epithelial cell proliferation | regulation of pH | regulation of kinase activity | response to wounding | import into cell | MAP kinase kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | mesenchymal cell differentiation | regulation of RNA biosynthetic process | regulation of body fluid levels | embryonic organ development | ear development | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | behavior | trachea development | immune response | nucleobase-containing compound metabolic process | protein kinase activity | cellular response to reactive oxygen species | neuron projection development | organic substance metabolic process | cell death | animal organ development | response to reactive oxygen species | gene expression | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | regulation of chromosome organization | mammary gland epithelium development | antigen receptor-mediated signaling pathway | Bergmann glial cell differentiation | transcription, DNA-templated | regulation of cellular pH | positive regulation of intracellular transport | cell activation | positive regulation of MAPK cascade | lung development | response to epidermal growth factor | stem cell development | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | sensory perception | regulation of stress-activated MAPK cascade | positive regulation of protein import into nucleus, translocation | regulation of cell communication | pyrimidine nucleobase metabolic process | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular monovalent inorganic cation homeostasis | cell development | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | protein serine/threonine/tyrosine kinase activity | response to biotic stimulus | reproductive structure development | regulation of developmental process | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | kinase activity | developmental process | regulation of DNA biosynthetic process | positive regulation of protein import | Fc receptor signaling pathway | peptidyl-serine phosphorylation | cellular protein modification process | Fc receptor mediated stimulatory signaling pathway | tube development | regulation of transport | positive regulation of transcription, DNA-templated | response to fibroblast growth factor | positive regulation of nucleic acid-templated transcription | neutrophil mediated immunity | response to organonitrogen compound | neural crest cell differentiation | lung morphogenesis | ERK1 and ERK2 cascade | heterocycle metabolic process | response to amino acid starvation | cellular response to dopamine | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | in utero embryonic development | positive regulation of metabolic process | regulation of synaptic plasticity | immune system process | cellular metabolic process | long-term synaptic potentiation | hematopoietic or lymphoid organ development | placenta development | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | positive regulation of cell motility | regulation of translation | circulatory system development | regulation of early endosome to late endosome transport | chemotaxis | ear morphogenesis | positive regulation of nucleocytoplasmic transport | neural crest cell development | phagocytosis | negative regulation of cell differentiation | regulation of cellular component organization | regulation of Golgi organization | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | cellular response to catecholamine stimulus | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | face development | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | azurophil granule lumen | dendrite | intracellular membrane-bounded organelle | late endosome | neuron projection | somatodendritic compartment | adherens junction | microtubule organizing center | focal adhesion | cytoplasmic vesicle | cell body | cell | nuclear lumen | neuronal cell body | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | dendrite cytoplasm | spindle | cell-substrate junction | intracellular organelle | membrane microdomain | dendritic tree | ficolin-1-rich granule lumen | Golgi apparatus | pseudopodium | protein-containing complex | cell projection | secretory vesicle | endomembrane system | nucleoplasm | plasma membrane bounded cell projection cytoplasm | plasma membrane | perikaryon | membrane raft | vacuole | vesicle | microtubule cytoskeleton | cytoplasmic region | mitochondrion | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | nucleus | organelle | lysosome | cell periphery | axon | membrane-enclosed lumen | azurophil granule | early endosome | cell-substrate adherens junction | secretory granule lumen | plasma membrane raft | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | mitotic spindle | caveola | membrane | vesicle lumen
