QuickView for MAPKAPK2 (gene)

Gene Symbol:

MAPKAPK2 Homo sapiens

Full name:

mitogen-activated protein kinase-activated protein kinase 2

Synonyms:

MAPKAP-K2, MK-2, MK2, MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2

Genomic Location:

Chr 1: 204924912-204974249

Description:

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation....

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This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  GAGCCTG_MIR484 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  SRF_Q6 ,  PEA3_Q6 ,  AAGCAAT_MIR137 ,  TGTATGA_MIR4853P ,  TEF1_Q6 ,  ETS2_B ,  ACCAAAG_MIR9 ,  SRF_Q4 ,  GTGCCTT_MIR506 ,  CETS1P54_01 ,  SCGGAAGY_ELK1_02 ,  SRF_Q5_01 ,  E2F_Q2 ,  CCAWWNAAGG_SRF_Q4

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-485-3p

Cytogenetic Map:

1q32.1

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