QuickView for MAPKBP1 (gene)

Gene Symbol:

MAPKBP1 Homo sapiens

Full name:

mitogen-activated protein kinase binding protein 1

Synonyms:

JNKBP-1, JNKBP1, NPHP20, mitogen-activated protein kinase-binding protein 1, JNK-binding protein 1

Genomic Location:

Chr 15: 39854004-39907345

Description:

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may ...

View Full Description

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Gallus gallus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAGCCAT_MIR135A_MIR135B ,  ACATTCC_MIR1_MIR206 ,  AGGGCAG_MIR18A ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  ACAGGGT_MIR10A_MIR10B

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

15q15.1

search → result