QuickView for MAPT (gene)
- Gene Symbol:
- MAPT
Homo sapiens - Full name:
- microtubule associated protein tau
- Synonyms:
- DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule-associated protein tau, G protein beta1/gamma2 subunit-interacting factor 1, PHF-tau, neurofibrillary tangle protein, paired helical filament-tau, protein phosphatase 1, regulatory subunit 103
- Genomic Location:
- Chr 17: 41327624-41461547
- Description:
-
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
17q21.31
GO Molecular Function
sequence-specific DNA binding | actin binding | kinase binding | protein phosphatase 2A binding | microtubule lateral binding | protein kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | lipid binding | SH3 domain binding | signaling receptor binding | single-stranded DNA binding | phospholipid binding | molecular function regulator | histone-dependent DNA binding | chaperone binding | lipoprotein particle binding | protein domain specific binding | cytoskeletal protein binding | protein binding, bridging | anion binding | phosphatidylinositol bisphosphate binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | ion binding | organic cyclic compound binding | molecular adaptor activity | apolipoprotein binding | protein binding | protein homodimerization activity | receptor regulator activity | double-stranded DNA binding | protein phosphatase binding | dynactin binding | protein dimerization activity | receptor ligand activity | phosphatidylinositol binding | microtubule binding | Hsp90 protein binding | tubulin binding | phosphatase binding | heat shock protein binding | AT DNA binding | heterocyclic compound binding | phosphatidylinositol phosphate binding | RNA binding
GO Biological Process
RNA metabolic process | negative regulation of phosphorylation | regulation of supramolecular fiber organization | regulation of cysteine-type endopeptidase activity | microtubule-based transport | regulation of microtubule polymerization or depolymerization | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of protein localization to synapse | regulation of neurogenesis | regulation of cellular localization | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | regulation of mitochondrial fission | establishment of localization | regulation of autophagy | astrocyte development | positive regulation of protein localization to synapse | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | response to metal ion | microtubule cytoskeleton organization | cell differentiation | nervous system development | negative regulation of mitochondrion organization | positive regulation of axonogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | intracellular transport | microtubule-based process | regulation of neuron death | negative regulation of mitochondrial membrane potential | cellular process | positive regulation of microtubule polymerization | establishment of organelle localization | localization | regulation of calcium-mediated signaling | regulation of mitochondrial membrane potential | neuron development | positive regulation of reactive oxygen species metabolic process | central nervous system neuron differentiation | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | establishment of localization in cell | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of cell differentiation | cytoskeleton-dependent intracellular transport | plus-end-directed organelle transport along microtubule | regulation of cellular process | microtubule polymerization | leukocyte activation | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | gliogenesis | regulation of protein complex assembly | organelle localization | response to nerve growth factor | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | regulation of cellular protein localization | regulation of cellular response to heat | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | organelle transport along microtubule | positive regulation of cellular protein localization | positive regulation of cysteine-type endopeptidase activity | supramolecular fiber organization | microtubule-based movement | cellular localization | positive regulation of superoxide anion generation | response to temperature stimulus | positive regulation of proteolysis | cellular nitrogen compound metabolic process | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | regulation of axon extension | protein modification process | modulation of chemical synaptic transmission | mitochondrion organization | macromolecule modification | cell-cell signaling | mitochondrion transport along microtubule | molecular function regulator | negative regulation of tubulin deacetylation | regulation of membrane potential | regulation of cellular response to stress | central nervous system neuron development | organelle assembly | regulation of superoxide metabolic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of phosphate metabolic process | positive regulation of diacylglycerol kinase activity | positive regulation of neuron projection development | astrocyte activation | multicellular organism development | negative regulation of catalytic activity | protein acetylation | regulation of peptidase activity | learning or memory | regulation of axonogenesis | protein complex oligomerization | regulation of catalytic activity | cellular response to oxidative stress | cellular response to nerve growth factor stimulus | regulation of phosphorylation | negative regulation of cellular protein localization | amyloid fibril formation | regulation of neuron differentiation | regulation of gene expression | axon development | cellular response to stress | nervous system process | cellular response to heat | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell projection organization | protein polymerization | positive regulation of protein complex assembly | response to oxidative stress | synapse organization | positive regulation of hydrolase activity | positive regulation of cell differentiation | cognition | mitochondrion localization | regulation of cellular protein metabolic process | glial cell differentiation | positive regulation of endopeptidase activity | cellular protein-containing complex assembly | positive regulation of neuron death | rRNA metabolic process | microglial cell activation | negative regulation of membrane potential | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of mitochondrion organization | regulation of long term synaptic depression | cell communication | regulation of cellular metabolic process | regulation of protein deacetylation | cytoplasmic microtubule organization | astrocyte differentiation | positive regulation of cytoskeleton organization | regulation of protein metabolic process | regulation of microtubule-based process | positive regulation of molecular function | positive regulation of axon extension | neuron differentiation | regulation of signaling receptor activity | receptor regulator activity | mitochondrion distribution | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | protein metabolic process | regulation of establishment of protein localization | regulation of growth | response to organic substance | establishment of mitochondrion localization, microtubule-mediated | regulation of kinase activity | establishment of mitochondrion localization | regulation of tubulin deacetylation | regulation of intracellular signal transduction | anatomical structure development | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | activation of cysteine-type endopeptidase activity involved in apoptotic process | transport along microtubule | behavior | positive regulation of cell death | receptor ligand activity | regulation of response to DNA damage stimulus | macrophage activation | stress granule assembly | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of gene expression | response to reactive oxygen species | negative regulation of cellular protein metabolic process | intracellular distribution of mitochondria | positive regulation of programmed cell death | cellular response to brain-derived neurotrophic factor stimulus | ribonucleoprotein complex assembly | positive regulation of kinase activity | response to heat | regulation of phosphate metabolic process | cytoskeleton organization | regulation of chromosome organization | microtubule polymerization or depolymerization | cell activation | memory | negative regulation of protein metabolic process | regulation of cell communication | axo-dendritic transport | negative regulation of molecular function | positive regulation of developmental growth | signaling | positive regulation of growth | glial cell development | neurofibrillary tangle assembly | cell development | regulation of developmental growth | internal protein amino acid acetylation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | regulation of endopeptidase activity | regulation of nervous system development | regulation of developmental process | developmental process | axonal transport of mitochondrion | organelle organization | regulation of cell growth | cellular protein modification process | regulation of reactive oxygen species metabolic process | negative regulation of mitochondrial fission | regulation of superoxide anion generation | positive regulation of protein polymerization | ncRNA metabolic process | heterocycle metabolic process | response to lead ion | central nervous system development | positive regulation of metabolic process | regulation of synaptic plasticity | positive regulation of neuron differentiation | ribonucleoprotein complex biogenesis | regulation of cell projection organization | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell morphogenesis involved in differentiation | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | axonal transport | regulation of cytoskeleton organization | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | negative regulation of establishment of protein localization to mitochondrion | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | dendritic spine | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | axolemma | somatodendritic compartment | cell projection membrane | cell body | cell | nuclear lumen | neuronal cell body | distal axon | ribonucleoprotein granule | microtubule | cytoplasm | intracellular organelle | membrane microdomain | nuclear body | dendritic tree | leading edge membrane | main axon | inclusion body | glial cell projection | protein-containing complex | cell projection | neuron spine | postsynapse | nucleoplasm | plasma membrane bounded cell projection cytoplasm | plasma membrane | cell leading edge | nuclear speck | membrane raft | ribonucleoprotein complex | microtubule cytoskeleton | cytoplasmic region | mitochondrion | site of polarized growth | extracellular region | membrane-bounded organelle | nucleus | organelle | axon cytoplasm | cytoplasmic ribonucleoprotein granule | cell periphery | axon | membrane-enclosed lumen | growth cone | cytosol | cytoskeleton | intracellular | neurofibrillary tangle | membrane | supramolecular complex | nuclear periphery | neuron projection membrane | tubulin complex
