QuickView for MASP1;jsessionid=910A938F17301737C429CF3ADC804AB7 (gene)

Gene Symbol:

MASP1 Homo sapiens

Full name:

mannan binding lectin serine peptidase 1

Synonyms:

3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF, mannan-binding lectin serine protease 1, C4/C2 activating component of Ra-reactive factor, Ra-reactive factor serine protease p100, complement factor MASP-3, complement-activating component of Ra-reactive factor, mannose-binding lectin-associated serine protease 1, mannose-binding protein-associated serine protease, serine protease 5

Genomic Location:

Chr 3: 188418632-188492446

Description:

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the...

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This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AGCYRWTTC_UNKNOWN ,  TGANTCA_AP1_C ,  ACACTCC_MIR122A ,  TTANTCA_UNKNOWN ,  GATA3_01 ,  AP3_Q6 ,  GATA_Q6 ,  GATA_C ,  GCANCTGNY_MYOD_Q6 ,  GATAAGR_GATA_C ,  GR_Q6_01 ,  E2A_Q2 ,  TGACCTY_ERR1_Q2 ,  TATAAA_TATA_01 ,  CAGGTG_E12_Q6 ,  CTCAGGG_MIR125B_MIR125A ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  AP4_01 ,  LMO2COM_02 ,  GATA6_01 ,  CTTTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  GATA1_02 ,  NRF2_Q4 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  WTTGKCTG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  ER_Q6_02 ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  ER_Q6 ,  TGACCTTG_SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-125

Cytogenetic Map:

3q27.3

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