QuickView for MCM7 (gene)

Gene Symbol:

MCM7 Homo sapiens

Full name:

minichromosome maintenance complex component 7

Synonyms:

CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104, DNA replication licensing factor MCM7, CDC47 homolog, homolog of S. cerevisiae Cdc47, minichromosome maintenance deficient 7, protein phosphatase 1, regulatory subunit 104

Genomic Location:

Chr 7: 99528340-99537363

Description:

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication for...

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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  RTAAACA_FREAC2_01 ,  GCGSCMNTTT_UNKNOWN ,  TFIIA_Q6 ,  FOX_Q2 ,  E2F1_Q4_01 ,  E2F4DP1_01 ,  E2F_Q6_01 ,  GGGYGTGNY_UNKNOWN ,  E2F_Q6 ,  FOXO3_01 ,  E2F1_Q6_01 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  GR_Q6 ,  E2F_Q4 ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  GCGNNANTTCC_UNKNOWN ,  E2F1_Q3_01 ,  FOXO1_01 ,  CTTTAAR_UNKNOWN ,  E2F_03 ,  E2F1DP1_01 ,  E2F_Q4_01 ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  E2F1DP1RB_01 ,  SCGGAAGY_ELK1_02 ,  E2F_02 ,  T3R_Q6 ,  E2F1_Q3 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  E2F4DP2_01 ,  GRE_C ,  CTTTGT_LEF1_Q2 ,  KTGGYRSGAA_UNKNOWN ,  SRY_02 ,  E2F_Q3 ,  ACCTGTTG_UNKNOWN ,  E2F_Q3_01 ,  FOXO4_02 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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Cytogenetic Map:

7q22.1

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