QuickView for MDA-5 (gene)

Gene Symbol:

IFIH1 Homo sapiens

Full name:

interferon induced with helicase C domain 1

Synonyms:

AGS7, Hlcd, IDDM19, MDA-5, MDA5, RLR-2, SGMRT1, interferon-induced helicase C domain-containing protein 1, CADM-140 autoantigen, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, RIG-I-like receptor 2, RNA helicase-DEAD box protein 116, clinically amyopathic dermatomyositis autoantigen 140 kDa, helicard, helicase with 2 CARD domains, melanoma differentiation-associated gene 5, melanoma differentiation-associated protein 5, murabutide down-regulated protein

Genomic Location:

Chr 2: 162831835-162883285

Description:

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patte...

View Full Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  STAT_Q6 ,  CDX2_Q5 ,  NKX62_Q2 ,  TTGTTT_FOXO4_01 ,  WTTGKCTG_UNKNOWN ,  ICSBP_Q6 ,  ISRE_01 ,  SRY_02 ,  YNGTTNNNATT_UNKNOWN

Cytogenetic Map:

2q24.2

search → result