QuickView for MDH1 (gene)

Gene Symbol:

MDH1 Homo sapiens

Full name:

malate dehydrogenase 1

Synonyms:

HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2, malate dehydrogenase, cytoplasmic, malate dehydrogenase, peroxisomal, cytosolic malate dehydrogenase, diiodophenylpyruvate reductase, epididymis secretory protein Li 32, malate dehydrogenase 1, NAD (soluble), soluble malate dehydrogenase

Genomic Location:

Chr 2: 63669626-63687832

Description:

This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, whi...

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This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  MIF1_01 ,  STAT6_01 ,  ATGGYGGA_UNKNOWN ,  CYTAGCAAY_UNKNOWN ,  RFX1_01 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  AACYNNNNTTCCS_UNKNOWN ,  ACTAYRNNNCCCR_UNKNOWN ,  HMGIY_Q6 ,  SNACANNNYSYAGA_UNKNOWN ,  TGACATY_UNKNOWN

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Cytogenetic Map:

2p15

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