QuickView for MED7 (gene)

Gene Symbol:

MED7 Homo sapiens

Full name:

mediator complex subunit 7

Synonyms:

ARC34, CRSP33, CRSP9, mediator of RNA polymerase II transcription subunit 7, CRSP complex subunit 9, RNA polymerase transcriptional regulation mediator subunit 7 homolog, activator-recruited cofactor 34 kDa component, cofactor required for Sp1 transcriptional activation subunit 9, cofactor required for Sp1 transcriptional activation, subunit 9 (33kD), cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa, transcriptional coactivator CRSP33

Genomic Location:

Chr 5: 156498029-156502499

Description:

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation)...

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The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

5q33.3

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