QuickView for MEPE (gene)

Gene Symbol:

MEPE Homo sapiens

Full name:

matrix extracellular phosphoglycoprotein

Synonyms:

OF45, matrix extracellular phosphoglycoprotein, matrix, extracellular phosphoglycoprotein with ASARM motif (bone), osteoblast/osteocyte factor 45

Genomic Location:

Chr 4: 88973164-88986968

Description:

This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone m...

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This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  TTCYRGAA_UNKNOWN ,  TGCTGAY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  GCTNWTTGK_UNKNOWN

Cytogenetic Map:

4q22.1

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