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QuickView for METTL3 (gene)


Gene Symbol:
METTL3 Homo sapiens Homo sapiens
Full name:
methyltransferase like 3
Synonyms:
IME4, M6A, MT-A70, Spo8, hMETTL3, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase 70 kDa subunit, adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase, mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase, mRNA m(6)A methyltransferase, methyltransferase-like protein 3
Genomic Location:
Chr 14: 21036122-21049297
Description:
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Saccharomyces cerevisiae Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 14
14q11.2





GO Molecular Function

cofactor binding | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | mRNA binding | coenzyme binding | catalytic activity | protein heterodimerization activity | organic cyclic compound binding | S-adenosyl-L-methionine binding | mRNA methyltransferase activity | protein binding | protein dimerization activity | transferase activity | RNA methyltransferase activity | drug binding | methyltransferase activity | heterocyclic compound binding | RNA binding

GO Biological Process

RNA metabolic process | gene silencing by RNA | brain development | response to radiation | cell morphogenesis | forebrain radial glial cell differentiation | positive regulation of macromolecule biosynthetic process | RNA processing | regulation of meiotic cell cycle | regulation of immune system process | negative regulation of cellular process | cell differentiation | regulation of T cell differentiation | male gamete generation | nervous system development | regulation of hematopoietic progenitor cell differentiation | production of small RNA involved in gene silencing by RNA | neurogenesis | generation of neurons | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | organic substance catabolic process | primary miRNA methylation | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity | negative regulation of signaling | dsRNA fragmentation | delamination | multicellular organismal reproductive process | stem cell population maintenance | dosage compensation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | gamete generation | positive regulation of mRNA catabolic process | regulation of mRNA stability | regulation of cellular process | gene silencing | regulation of metabolic process | gliogenesis | catabolic process | production of miRNAs involved in gene silencing by miRNA | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cellular component organization | mRNA catabolic process | response to UV | head development | regulation of translational initiation | RNA modification | response to stimulus | RNA splicing | RNA methylation | positive regulation of protein metabolic process | negative regulation of cell adhesion | cellular response to light stimulus | response to stress | RNA splicing, via transesterification reactions | posttranscriptional regulation of gene expression | circadian rhythm | ncRNA processing | reproduction | rhythmic process | cellular nitrogen compound metabolic process | mRNA modification | cellular response to organic cyclic compound | negative regulation of metabolic process | mRNA metabolic process | regulation of cell adhesion | macromolecule modification | nucleobase-containing compound catabolic process | regulation of lymphocyte differentiation | primary miRNA processing | response to nitrogen compound | endothelial to hematopoietic transition | response to light stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | response to dsRNA | cellular response to DNA damage stimulus | regulation of T cell activation | regulation of hematopoietic stem cell differentiation | regulation of gene expression | methylation | cellular response to stress | gene silencing by miRNA | RNA catabolic process | positive regulation of cellular metabolic process | regulation of lymphocyte activation | cellular response to radiation | regulation of nitrogen compound metabolic process | regulation of Notch signaling pathway | dosage compensation by inactivation of X chromosome | regulation of RNA stability | radial glial cell differentiation | regulation of cellular protein metabolic process | glial cell differentiation | cell morphogenesis involved in differentiation | positive regulation of cap-independent translational initiation | cellular response to UV | negative regulation of cell-cell adhesion | mRNA destabilization | posttranscriptional gene silencing | regulation of cellular metabolic process | regulation of protein metabolic process | mRNA methyltransferase activity | aromatic compound catabolic process | cellular response to dsRNA | regulation of RNA metabolic process | regulation of stem cell differentiation | positive regulation of cytoplasmic translational initiation | positive regulation of translational initiation | multicellular organism reproduction | posttranscriptional gene silencing by RNA | response to organic substance | regulation of hemopoiesis | mRNA methylation | cellular macromolecule catabolic process | anatomical structure development | metabolic process | base conversion or substitution editing | forebrain generation of neurons | adenosine to inosine editing | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | regulation of mRNA catabolic process | forebrain development | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | RNA destabilization | positive regulation of cytoplasmic translation | negative regulation of translation | regulation of cytoplasmic translation | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | response to organic cyclic compound | RNA methyltransferase activity | cell development | anatomical structure morphogenesis | regulation of developmental process | methyltransferase activity | developmental process | spermatogenesis | regulation of cell-cell adhesion | ncRNA metabolic process | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | negative regulation of Notch signaling pathway | cellular metabolic process | mRNA processing | cellular response to organic substance | regulation of translation | sexual reproduction | mRNA splicing, via spliceosome | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

mRNA editing complex | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | RNA N6-methyladenosine methyltransferase complex | nuclear body | protein-containing complex | methyltransferase complex | nucleoplasm | nuclear speck | transferase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular