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QuickView for MFF (gene)


Gene Symbol:
MFF Homo sapiens Homo sapiens
Full name:
mitochondrial fission factor
Synonyms:
C2orf33, EMPF2, GL004, mitochondrial fission factor
Genomic Location:
Chr 2: 227900472-227930793
Description:
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q36.3





GO Molecular Function

identical protein binding | protein binding | protein homodimerization activity | protein dimerization activity

GO Biological Process

protein homooligomerization | regulation of intracellular protein transport | peroxisome organization | release of cytochrome c from mitochondria | positive regulation of cellular component organization | regulation of cellular localization | positive regulation of apoptotic process | protein localization to mitochondrion | regulation of localization | organelle fusion | peroxisome fission | regulation of programmed cell death | regulation of mitochondrial fission | establishment of localization | membrane fusion | positive regulation of developmental process | regulation of protein localization to membrane | cell part morphogenesis | regulation of organelle organization | membrane organization | intracellular transport | cellular process | localization | mitochondrial fragmentation involved in apoptotic process | protein transport | mitochondrial fusion | establishment of protein localization to mitochondrion | macromolecule localization | positive regulation of release of cytochrome c from mitochondria | establishment of localization in cell | regulation of cellular process | regulation of apoptotic process | cellular component organization | mitochondrion morphogenesis | response to stimulus | regulation of cellular protein localization | intracellular protein transport | positive regulation of cellular protein localization | programmed cell death | cellular localization | apoptotic mitochondrial changes | regulation of protein transport | cellular component assembly | regulation of peptide transport | mitochondrion organization | regulation of intracellular transport | positive regulation of mitochondrion organization | apoptotic process | regulation of signal transduction | positive regulation of organelle organization | protein complex oligomerization | organic substance transport | positive regulation of intracellular protein transport | mitochondrial transport | peptide transport | protein localization to organelle | regulation of apoptotic signaling pathway | regulation of mitochondrion organization | regulation of peroxisome organization | cell communication | positive regulation of protein localization to membrane | positive regulation of signal transduction | positive regulation of establishment of protein localization | positive regulation of transport | apoptotic signaling pathway | protein-containing complex assembly | regulation of establishment of protein localization | establishment of protein localization to organelle | anatomical structure development | regulation of protein targeting | cellular protein localization | amide transport | positive regulation of cell death | cell death | positive regulation of programmed cell death | establishment of protein localization | positive regulation of intracellular transport | positive regulation of protein transport | regulation of cell communication | signaling | positive regulation of mitochondrial fission | protein localization | anatomical structure morphogenesis | cellular macromolecule localization | regulation of developmental process | protein targeting to mitochondrion | developmental process | organelle organization | positive regulation of protein targeting to membrane | regulation of transport | protein targeting | mitochondrial fission | regulation of protein localization | regulation of cell death | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling

GO Cellular Component

integral component of organelle membrane | exocytic vesicle | integral component of membrane | intracellular membrane-bounded organelle | synapse | organelle membrane | peroxisome | cytoplasmic vesicle | cell | organelle outer membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | presynapse | secretory vesicle | endomembrane system | vesicle | transport vesicle | mitochondrion | synaptic vesicle | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | outer membrane | integral component of mitochondrial membrane | mitochondrial membrane | intracellular vesicle | intracellular | cell junction | membrane