QuickView for MGEA5 (gene)
- Gene Symbol:
- MGEA5
Homo sapiens - Full name:
- meningioma expressed antigen 5 (hyaluronidase)
- Synonyms:
- MEA5, NCOAT, OGA, protein O-GlcNAcase, N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-glucosaminidase, O-GlcNAcase, beta-N-acetylglucosaminidase, beta-N-acetylhexosaminidase, beta-hexosaminidase, bifunctional protein NCOAT, hyaluronidase in meningioma, meningioma-expressed antigen 5, nuclear cytoplasmic O-GlcNAcase and acetyltransferase
- Genomic Location:
- Chr 10: 103534199-103568165
- Description:
-
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10q24.32
GO Molecular Function
hexosaminidase activity | hyalurononglucosaminidase activity | hydrolase activity | hydrolase activity, hydrolyzing O-glycosyl compounds | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity | catalytic activity | beta-N-acetylhexosaminidase activity | beta-N-acetylglucosaminidase activity | hydrolase activity, acting on glycosyl bonds | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity
GO Biological Process
cellular process | organic substance catabolic process | carbohydrate derivative catabolic process | glycoprotein biosynthetic process | catabolic process | N-acetylglucosamine metabolic process | protein deglycosylation | carbohydrate derivative biosynthetic process | protein modification process | macromolecule glycosylation | cellular biosynthetic process | macromolecule modification | nitrogen compound metabolic process | protein catabolic process | biosynthetic process | protein metabolic process | cellular macromolecule catabolic process | metabolic process | organic substance metabolic process | protein O-linked glycosylation | organonitrogen compound catabolic process | cellular protein metabolic process | cellular macromolecule biosynthetic process | cellular protein modification process | carbohydrate derivative metabolic process | protein glycosylation | glycosylation | cellular metabolic process | glycoprotein catabolic process | glycoprotein metabolic process | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular | membrane
