QuickView for MLLT10 (gene)
- Gene Symbol:
- MLLT10
Homo sapiens - Full name:
- MLLT10, histone lysine methyltransferase DOT1L cofactor
- Synonyms:
- AF10, protein AF-10, ALL1-fused gene from chromosome 10 protein, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10, type I AF10 protein, type III AF10 protein, type IV AF10 protein
- Genomic Location:
- Chr 10: 21863108-22072560
- Description:
-
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-130 , Predicted Gene Targets for miR-148 , Predicted Gene Targets for miR-214 , Predicted Gene Targets for miR-30-3p , Predicted Gene Targets for miR-330 , Predicted Gene Targets for miR-331 , Predicted Gene Targets for miR-381 , Predicted Gene Targets for miR-376 , Predicted Gene Targets for miR-493-5p
- Cytogenetic Map:
-
10p12.31
GO Molecular Function
cation binding | nucleosome binding | nucleic acid binding | protein-containing complex binding | chromatin binding | DNA binding | ion binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | histone binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular biosynthetic process | cellular process | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
