QuickView for MME (gene)

Gene Symbol:

MME Homo sapiens

Full name:

membrane metalloendopeptidase

Synonyms:

CALLA, CD10, CMT2T, NEP, SCA43, SFE, neprilysin, atriopeptidase, common acute lymphocytic leukemia antigen, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), membrane metallo-endopeptidase variant 1, membrane metallo-endopeptidase variant 2, neprilysin-390, neprilysin-411, neutral endopeptidase 24.11, skin fibroblast elastase

Genomic Location:

Chr 3: 156280130-156384212

Description:

The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not re...

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The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CACTGTG_MIR128A_MIR128B ,  TGANTCA_AP1_C ,  CTTTGA_LEF1_Q2 ,  TCF4_Q5

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

3q25.2

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