QuickView for MMP13 (gene)

Gene Symbol:

MMP13 Homo sapiens

Full name:

matrix metallopeptidase 13

Synonyms:

CLG3, MANDP1, MDST, MMP-13, collagenase 3, matrix metalloproteinase 13 (collagenase 3)

Genomic Location:

Chr 11: 102318934-102331672

Description:

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encode...

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This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  TGANTCA_AP1_C ,  IRF1_Q6 ,  AML1_01 ,  OSF2_Q6 ,  TATAAA_TATA_01 ,  RREB1_01 ,  TATA_C ,  AML1_Q6 ,  FREAC2_01 ,  AACTTT_UNKNOWN ,  COREBINDINGFACTOR_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-140

Cytogenetic Map:

11q22.2

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