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QuickView for MNAT1;jsessionid=D1CA88507E2E0E9873505255524FB75E (gene)


Gene Symbol:
MNAT1 Homo sapiens Homo sapiens
Full name:
MNAT1, CDK activating kinase assembly factor
Synonyms:
CAP35, MAT1, RNF66, TFB3, CDK-activating kinase assembly factor MAT1, CDK7/cyclin-H assembly factor, MNAT CDK-activating kinase assembly factor 1, RING finger protein 66, RING finger protein MAT1, cyclin G1 interacting protein, menage a trois 1 (CAK assembly factor), menage a trois homolog 1, cyclin H assembly factor, menage a trois-like protein 1 cyclin H assembly factor
Genomic Location:
Chr 14: 60271223-60505151
Description:
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 14
14q23.1





GO Molecular Function

protein kinase activator activity | protein serine/threonine kinase activator activity | enzyme activator activity | protein kinase regulator activity | cation binding | kinase regulator activity | cyclin-dependent protein serine/threonine kinase activator activity | hydrolase activity | protein serine/threonine kinase activity | ATPase activity | pyrophosphatase activity | RNA polymerase II CTD heptapeptide repeat kinase activity | molecular function regulator | catalytic activity | protein N-terminus binding | nucleoside-triphosphatase activity | ATPase activity, coupled | ion binding | protein binding | zinc ion binding | kinase activator activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | hydrolase activity, acting on acid anhydrides | protein kinase activity | transferase activity | transition metal ion binding | enzyme regulator activity | DNA-dependent ATPase activity | kinase activity | metal ion binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | cyclin-dependent protein serine/threonine kinase regulator activity

GO Biological Process

positive regulation of cyclin-dependent protein serine/threonine kinase activity | RNA metabolic process | transcription by RNA polymerase II | positive regulation of smooth muscle cell proliferation | brain development | DNA-templated transcription, initiation | protein kinase activator activity | positive regulation of macromolecule biosynthetic process | protein serine/threonine kinase activator activity | RNA processing | enzyme activator activity | protein kinase regulator activity | regulation of programmed cell death | transcription initiation from RNA polymerase I promoter | negative regulation of cellular process | response to metal ion | nervous system development | positive regulation of phosphate metabolic process | positive regulation of cellular biosynthetic process | cellular process | 7-methylguanosine mRNA capping | kinase regulator activity | cyclin-dependent protein serine/threonine kinase activator activity | positive regulation of protein kinase activity | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cyclin-dependent protein kinase activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | ventricular system development | head development | response to stimulus | positive regulation of protein metabolic process | response to stress | transcription by RNA polymerase I | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | protein serine/threonine kinase activity | protein-DNA complex assembly | cellular nitrogen compound metabolic process | cell cycle G1/S phase transition | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | mRNA metabolic process | RNA polymerase II CTD heptapeptide repeat kinase activity | cellular biosynthetic process | macromolecule modification | activation of protein kinase activity | molecular function regulator | DNA repair | regulation of nucleic acid-templated transcription | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | multicellular organism development | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cell cycle | regulation of gene expression | cellular response to stress | cell cycle | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | cellular protein-containing complex assembly | transcription elongation from RNA polymerase II promoter | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | heart development | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | DNA-templated transcription, termination | positive regulation of molecular function | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | regulation of kinase activity | DNA metabolic process | anatomical structure development | kinase activator activity | mitotic cell cycle | metabolic process | nucleotide-excision repair | regulation of RNA biosynthetic process | negative regulation of programmed cell death | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | animal organ development | gene expression | positive regulation of kinase activity | regulation of phosphate metabolic process | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | transcription-coupled nucleotide-excision repair | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | cellular macromolecule biosynthetic process | kinase activity | developmental process | cellular protein modification process | positive regulation of transcription, DNA-templated | 7-methylguanosine RNA capping | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | response to calcium ion | central nervous system development | positive regulation of metabolic process | cellular metabolic process | mRNA processing | adult heart development | regulation of cell death | regulation of smooth muscle cell proliferation | negative regulation of cell death | circulatory system development | termination of RNA polymerase I transcription | nucleotide-excision repair, preincision complex assembly | positive regulation of gene expression | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | multicellular organismal process | DNA-templated transcription, elongation | regulation of phosphorus metabolic process

GO Cellular Component

nuclear transcription factor complex | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | protein kinase complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | carboxy-terminal domain protein kinase complex | protein-containing complex | nucleoplasm | transferase complex | serine/threonine protein kinase complex | membrane-bounded organelle | holo TFIIH complex | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | RNA polymerase complex | membrane-enclosed lumen | cytosol | intracellular | RNA polymerase II, holoenzyme