QuickView for MSRB3;jsessionid=452333ADFD07666B587F4F86A86F2139 (gene)
- Gene Symbol:
- MSRB3
Homo sapiens - Full name:
- methionine sulfoxide reductase B3
- Synonyms:
- DFNB74, methionine-R-sulfoxide reductase B3, methionine-R-sulfoxide reductase B3, mitochondrial
- Genomic Location:
- Chr 12: 63958755-64146954
- Description:
-
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12q14.3
GO Molecular Function
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | cation binding | peptide-methionine (R)-S-oxide reductase activity | catalytic activity | oxidoreductase activity, acting on a sulfur group of donors | ion binding | protein binding | zinc ion binding | transition metal ion binding | L-methionine-(R)-S-oxide reductase activity | metal ion binding | oxidoreductase activity
GO Biological Process
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | cellular process | peptide-methionine (R)-S-oxide reductase activity | response to stimulus | response to stress | nitrogen compound metabolic process | cellular response to oxidative stress | oxidoreductase activity, acting on a sulfur group of donors | cellular response to stress | response to oxidative stress | protein metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | protein repair | L-methionine-(R)-S-oxide reductase activity | cellular protein metabolic process | cellular metabolic process | oxidoreductase activity | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endomembrane system | mitochondrion | membrane-bounded organelle | organelle | cytosol | intracellular
