QuickView for MYOD1;jsessionid=10686A930C097BFFA0355ABF94046A75 (gene)
- Gene Symbol:
- MYOD1
Homo sapiens - Full name:
- myogenic differentiation 1
- Synonyms:
- MYF3, MYOD, PUM, bHLHc1, myoblast determination protein 1, class C basic helix-loop-helix protein 1, myf-3, myogenic factor 3
- Genomic Location:
- Chr 11: 17697686-17700254
- Description:
-
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription whi...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
11p15.1
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | hormone receptor binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | signaling receptor binding | chromatin binding | ubiquitin-like protein ligase binding | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | nuclear hormone receptor binding | protein heterodimerization activity | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | chromatin DNA binding | ubiquitin protein ligase binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | positive regulation of striated muscle cell differentiation | regulation of myoblast fusion | myoblast fusion | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to cytokine | positive regulation of cellular component organization | muscle tissue development | positive regulation of skeletal muscle tissue development | regulation of cell development | syncytium formation by plasma membrane fusion | positive regulation of striated muscle tissue development | peptidyl-amino acid modification | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | cellular response to tumor necrosis factor | histone modification | cell differentiation | striated muscle cell development | cellular response to extracellular stimulus | histone H3 acetylation | regulation of mRNA processing | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | regulation of syncytium formation by plasma membrane fusion | developmental growth | myotube cell development | response to estradiol | regulation of striated muscle tissue development | cellular response to starvation | positive regulation of nitrogen compound metabolic process | tissue development | regulation of cell differentiation | positive regulation of muscle cell differentiation | muscle structure development | muscle cell differentiation | skeletal muscle organ development | regulation of myotube differentiation | regeneration | regulation of cellular process | cellular response to lipid | regulation of skeletal muscle fiber development | regulation of metabolic process | regulation of mRNA splicing, via spliceosome | myotube differentiation involved in skeletal muscle regeneration | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of skeletal muscle tissue regeneration | histone H4 acetylation | response to stimulus | muscle cell development | response to stress | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | response to starvation | peptidyl-lysine acetylation | cellular nitrogen compound metabolic process | positive regulation of myoblast differentiation | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | regulation of wound healing | protein modification process | cellular biosynthetic process | macromolecule modification | muscle fiber development | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | regulation of skeletal muscle tissue development | system development | cellular response to nutrient levels | response to oxygen levels | positive regulation of response to wounding | nitrogen compound metabolic process | multicellular organism development | protein acetylation | syncytium formation | phosphorus metabolic process | positive regulation of skeletal muscle fiber development | positive regulation of muscle organ development | wound healing | regulation of gene expression | myoblast fate commitment | cellular response to stress | response to lipid | positive regulation of cellular metabolic process | skeletal muscle fiber adaptation | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | positive regulation of syncytium formation by plasma membrane fusion | response to corticosteroid | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | cellular response to cytokine stimulus | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | aromatic compound biosynthetic process | cellular response to glucocorticoid stimulus | phosphorylation | protein phosphorylation | cellular response to corticosteroid stimulus | phosphate-containing compound metabolic process | regulation of alternative mRNA splicing, via spliceosome | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of skeletal muscle tissue regeneration | transcription coactivator activity | regulation of RNA metabolic process | striated muscle cell differentiation | negative regulation of myoblast proliferation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | skeletal muscle adaptation | regulation of growth | response to organic substance | myoblast fate determination | response to wounding | anatomical structure development | metabolic process | positive regulation of cell development | cell fate commitment | regulation of RNA splicing | regulation of RNA biosynthetic process | regulation of myoblast differentiation | regulation of myoblast proliferation | peptidyl-lysine modification | positive regulation of myoblast fusion | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of striated muscle cell differentiation | positive regulation of wound healing | muscle cell fate commitment | cellular response to steroid hormone stimulus | positive regulation of muscle tissue development | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | skeletal muscle tissue regeneration | cellular response to estradiol stimulus | regulation of response to wounding | positive regulation of developmental growth | covalent chromatin modification | positive regulation of growth | regulation of transcription, DNA-templated | myotube differentiation | response to organic cyclic compound | myoblast differentiation | cell development | regulation of developmental growth | internal protein amino acid acetylation | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | organelle organization | regulation of muscle cell differentiation | cellular protein modification process | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | cell fate determination | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | response to steroid hormone | tissue regeneration | skeletal muscle cell differentiation | regulation of cellular component organization | muscle organ development | muscle system process | positive regulation of snRNA transcription by RNA polymerase II | positive regulation of myotube differentiation | positive regulation of gene expression | response to glucocorticoid | skeletal muscle fiber development | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
supramolecular fiber | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | myofibril | cytoplasm | intracellular organelle | nuclear body | contractile fiber | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular | supramolecular complex
