QuickView for MuRF1 (gene)

Gene Symbol:

TRIM63 Homo sapiens

Full name:

tripartite motif containing 63

Synonyms:

IRF, MURF1, MURF2, RNF28, SMRZ, E3 ubiquitin-protein ligase TRIM63, RING-type E3 ubiquitin transferase TRIM63, iris ring finger protein, muscle specific ring finger protein 2, muscle-specific RING finger protein 1, ring finger protein 28, striated muscle RING zinc finger protein, tripartite motif containing 63, E3 ubiquitin protein ligase, tripartite motif-containing protein 63

Genomic Location:

Chr 1: 26250385-26266708

Description:

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy...

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This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  FOXO1_02 ,  CTTGTAT_MIR381 ,  RTAAACA_FREAC2_01 ,  PR_02 ,  TCANNTGAY_SREBP1_01 ,  PR_01 ,  LYF1_01 ,  CTAWWWATA_RSRFC4_Q2 ,  AR_02 ,  TATAAA_TATA_01 ,  FOXO3_01 ,  TEF1_Q6 ,  AR_01 ,  AR_03 ,  FOXO1_01 ,  AATGTGA_MIR23A_MIR23B ,  TTGTTT_FOXO4_01 ,  GR_01 ,  RGAGGAARY_PU1_Q6 ,  SREBP_Q3 ,  GRE_C ,  TBP_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

1p36.11

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