QuickView for Muc-1 (gene)
- Gene Symbol:
- MUC1
Homo sapiens - Full name:
- mucin 1, cell surface associated
- Synonyms:
- ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin-1, H23 antigen, breast carcinoma-associated antigen DF3, cancer antigen 15-3, carcinoma-associated mucin, episialin, krebs von den Lungen-6, mucin 1, transmembrane, peanut-reactive urinary mucin, polymorphic epithelial mucin, tumor associated epithelial mucin, tumor-associated epithelial membrane antigen
- Genomic Location:
- Chr 1: 153424924-153429324
- Description:
-
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mu...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1q22
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | p53 binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
positive regulation of immune response | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | response to cytokine | positive regulation of cellular component organization | immune response-regulating signaling pathway | intracellular signal transduction | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | immune response-activating cell surface receptor signaling pathway | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of organelle organization | innate immune response activating cell surface receptor signaling pathway | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | mitotic DNA integrity checkpoint | negative regulation of signaling | negative regulation of G1/S transition of mitotic cell cycle | negative regulation of nucleic acid-templated transcription | regulation of histone modification | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | glycoprotein biosynthetic process | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | signal transduction involved in mitotic DNA damage checkpoint | positive regulation of histone H4 acetylation | response to stimulus | positive regulation of innate immune response | regulation of mitotic cell cycle phase transition | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | response to stress | regulation of cell cycle phase transition | activation of innate immune response | immune response-activating signal transduction | carbohydrate derivative biosynthetic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | macromolecule glycosylation | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | cellular response to DNA damage stimulus | regulation of intrinsic apoptotic signaling pathway | positive regulation of chromosome organization | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | regulation of histone H4 acetylation | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | negative regulation of signal transduction by p53 class mediator | cytokine-mediated signaling pathway | regulation of transcription by RNA polymerase II | cellular response to cytokine stimulus | biosynthetic process | regulation of cellular protein metabolic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | regulation of cell adhesion mediated by integrin | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of RNA metabolic process | positive regulation of protein acetylation | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | activation of immune response | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | G1 DNA damage checkpoint | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | negative regulation of intracellular signal transduction | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | regulation of response to DNA damage stimulus | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of histone modification | signal transduction involved in mitotic cell cycle checkpoint | protein O-linked glycosylation | regulation of chromosome organization | negative regulation of cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | cellular macromolecule biosynthetic process | signal transduction involved in DNA damage checkpoint | negative regulation of transcription by competitive promoter binding | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | positive regulation of cell cycle process | cellular protein modification process | mitotic G1/S transition checkpoint | regulation of histone acetylation | positive regulation of histone acetylation | carbohydrate derivative metabolic process | positive regulation of transcription, DNA-templated | negative regulation of cell adhesion mediated by integrin | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | stimulatory C-type lectin receptor signaling pathway | positive regulation of transcription by RNA polymerase II | signal transduction involved in mitotic G1 DNA damage checkpoint | protein glycosylation | glycosylation | positive regulation of metabolic process | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | glycoprotein metabolic process | regulation of cellular component organization | signal transduction | regulation of signaling | O-glycan processing | positive regulation of gene expression | macromolecule metabolic process | regulation of chromatin organization
GO Cellular Component
integral component of membrane | chromosome | intracellular membrane-bounded organelle | apical plasma membrane | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | apical part of cell | Golgi apparatus | endomembrane system | plasma membrane | chromatin | nuclear chromosome | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | nuclear chromatin | intracellular | membrane | intrinsic component of plasma membrane | Golgi lumen
