QuickView for Mxi1 (gene)

Gene Symbol:

MXI1 Homo sapiens

Full name:

MAX interactor 1, dimerization protein

Synonyms:

MAD2, MXD2, MXI, bHLHc11, max-interacting protein 1, MAX dimerization protein 2, Max-related transcription factor, class C basic helix-loop-helix protein 11

Genomic Location:

Chr 10: 111957353-112037113

Description:

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the tra...

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Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  CACTGTG_MIR128A_MIR128B ,  IRF1_01 ,  CMYB_01 ,  HNF4ALPHA_Q6 ,  TGIF_01 ,  GTGTTGA_MIR505 ,  CEBPA_01 ,  GCATTTG_MIR105 ,  MZF1_01 ,  FOXJ2_02 ,  P53_DECAMER_Q2 ,  FOXO4_01 ,  YTATTTTNR_MEF2_02 ,  GCAAGGA_MIR502 ,  YATTNATC_UNKNOWN ,  AREB6_04 ,  WGTTNNNNNAAA_UNKNOWN ,  SRY_01 ,  TACTTGA_MIR26A_MIR26B ,  HNF1_C ,  TTTNNANAGCYR_UNKNOWN ,  TTF1_Q6 ,  COUP_01 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  ATCATGA_MIR433 ,  DBP_Q6 ,  TCTGATA_MIR361 ,  TITF1_Q3 ,  YYCATTCAWW_UNKNOWN ,  RREB1_01 ,  CAGCTTT_MIR320 ,  TGCTGAY_UNKNOWN ,  RAAGNYNNCTTY_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  SOX5_01 ,  AHRARNT_01 ,  RNGTGGGC_UNKNOWN ,  CEBP_Q3 ,  TTGTTT_FOXO4_01 ,  CTGAGCC_MIR24 ,  T3R_Q6 ,  ICSBP_Q6 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  CDC5_01 ,  SRY_02 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  YNGTTNNNATT_UNKNOWN ,  ER_Q6 ,  STTTCRNTTT_IRF_Q6 ,  PAX4_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-544

Cytogenetic Map:

10q25.2

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