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QuickView for Myeloid differentiation primary response protein MyD88 (biogroup)
- Description:
- Myeloid differentiation primary response protein MyD88 is an intracellular adaptor protein that has an essential role in innate immune signalling. It is vital for the proper responses of interleukin-1 and interleukin-18 and nearly all toll-like receptors (except TLR3) in the activation of transcription factors NF-kappa B and AP-1 followed by the induction of pro-inflammatory genes. MyD88 contains a TIR (Toll/Interleukin-1 receptor) domain and a death domain. The TIR domain is important for the protein's interaction with receptors, while the death domain is involved in signal transduction. For example, MyD88 interacts with IL-1R-associated kinase (IRAK)-4 through its death domain, and in turn, IRAK-4 activates other members of the IRAK family, like IRAK-1. Defects in MYD88 are the cause of MYD88 deficiency, also known as as recurrent pyogenic bacterial infections due to MYD88 deficiency.
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