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QuickView for N-cadherin (gene)


Gene Symbol:
Cdh2 Mus musculus Mus musculus
Full name:
cadherin 2
Synonyms:
CDHN, N-CAD, Ncad, cadherin-2, N-cadherin, neural cadherin
Genomic Location:
Chr 18: 16747518-16967755
Description:
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death.
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_007664
XM_006525553
Protein Names
Q6GU11
Q8BSI9
Q64260
Q3UIC2
P15116



GO Molecular Function

beta-catenin binding | kinase binding | cadherin binding | cation binding | protein kinase binding | enzyme binding | protein-containing complex binding | cytoskeletal protein binding | gamma-catenin binding | identical protein binding | ion binding | cell adhesion molecule binding | protein binding | protein homodimerization activity | protein phosphatase binding | alpha-catenin binding | protein dimerization activity | nitric-oxide synthase binding | calcium ion binding | phosphatase binding | metal ion binding

GO Biological Process

brain development | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | protein localization to cell periphery | regulation of cellular localization | regulation of cell development | regulation of localization | negative regulation of cellular process | cell-cell adhesion mediated by cadherin | regulation of protein localization to membrane | cell differentiation | neuroligin clustering involved in postsynaptic membrane assembly | nervous system development | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | membrane organization | membrane biogenesis | blood vessel morphogenesis | cellular process | localization | negative regulation of signaling | synapse assembly | stem cell population maintenance | macromolecule localization | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of canonical Wnt signaling pathway | tissue development | regulation of cell differentiation | muscle structure development | muscle cell differentiation | cell junction assembly | regulation of cellular process | regulation of metabolic process | gliogenesis | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | head development | vasculature development | regulation of cellular protein localization | positive regulation of protein metabolic process | regulation of oligodendrocyte progenitor proliferation | regulation of cell proliferation | tube morphogenesis | postsynaptic membrane assembly | receptor clustering | cellular localization | cardiovascular system development | brain morphogenesis | cellular component assembly | regulation of synapse structure or activity | modulation of chemical synaptic transmission | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | blood vessel development | locomotion | system development | regulation of signal transduction | adherens junction organization | multicellular organism development | cell migration | regulation of synaptic transmission, glutamatergic | regulation of MAPK cascade | neuroepithelial cell differentiation | regulation of axonogenesis | protein complex oligomerization | regulation of phosphorylation | localization within membrane | telencephalon development | protein localization to plasma membrane | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | protein localization to membrane | regulation of postsynaptic membrane organization | membrane assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of myelination | regulation of synapse organization | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | synapse organization | radial glial cell differentiation | homeostasis of number of cells | regulation of Rho protein signal transduction | regulation of cellular protein metabolic process | glial cell differentiation | regulation of synaptic vesicle clustering | postsynapse assembly | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of protein phosphorylation | postsynaptic membrane organization | positive regulation of transport | cerebral cortex development | striated muscle cell differentiation | neuronal stem cell population maintenance | regulation of postsynaptic density protein 95 clustering | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | positive regulation of protein modification process | regulation of intracellular signal transduction | anatomical structure development | regulation of neural precursor cell proliferation | cell-cell junction assembly | cellular protein localization | cell adhesion | maintenance of cell number | animal organ development | forebrain development | pallium development | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | cell-cell adhesion | regulation of postsynapse organization | positive regulation of MAPK cascade | regulation of cell communication | regulation of gliogenesis | negative regulation of signal transduction | positive regulation of synaptic vesicle clustering | protein localization | positive regulation of phosphorylation | regulation of Ras protein signal transduction | protein heterooligomerization | anatomical structure morphogenesis | cellular macromolecule localization | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | tube development | regulation of transport | epithelial cell differentiation | central nervous system development | cell-cell adhesion via plasma-membrane adhesion molecules | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | regulation of cell projection organization | regulation of protein localization | circulatory system development | regulation of cellular component organization | positive regulation of signaling | regulation of signaling | homophilic cell adhesion via plasma membrane adhesion molecules | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process

GO Cellular Component

presynaptic membrane | intercalated disc | integral component of membrane | sarcolemma | synapse | integral component of presynaptic active zone membrane | apical plasma membrane | neuron projection | extrinsic component of membrane | catenin complex | adherens junction | integral component of presynaptic membrane | postsynaptic specialization membrane | fascia adherens | cell | plasma membrane protein complex | extrinsic component of plasma membrane | intrinsic component of membrane | synaptic membrane | lamellipodium | cytoplasm | cortical cytoskeleton | intracellular organelle | actin cytoskeleton | membrane microdomain | apical part of cell | cell-cell adherens junction | presynapse | cell-cell junction | cell-cell contact zone | protein-containing complex | cell projection | postsynaptic membrane | postsynapse | plasma membrane | cell leading edge | membrane raft | postsynaptic density | asymmetric synapse | cytoplasmic region | integral component of postsynaptic membrane | integral component of plasma membrane | T-tubule | presynaptic active zone membrane | cortical actin cytoskeleton | cell cortex | organelle | postsynaptic specialization | presynaptic active zone | cell periphery | basolateral plasma membrane | plasma membrane raft | cell surface | cytoskeleton | intracellular | cell junction | membrane | integral component of postsynaptic specialization membrane | intrinsic component of plasma membrane