QuickView for N-ethylmaleimide-sensitive factor (gene)
- Gene Symbol:
- Nsf
Rattus norvegicus - Full name:
- N-ethylmaleimide sensitive factor, vesicle fusing ATPase
- Synonyms:
- vesicle-fusing ATPase, N-ethylmaleimide-sensitive factor, N-ethylmaleimide-sensitive fusion protein, NEM-sensitive fusion protein, vesicular-fusion protein NSF
- Genomic Location:
- Chr 10: 92974385-93082222
- Description:
-
binds AMPA receptor GluR2 subunit and acts to disrupt GluR2-PICK1 interactions; may play a role in AMPA receptor trafficking and stabilization
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_04 , SRY_02 , MYCMAX_B , WHN_B , POU3F2_01 , ZF5_01 , SREBP1_Q6 , CTCAAGA_MIR526B , TTGTTT_FOXO4_01 , GGATTA_PITX2_Q2
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
kinase binding | GTPase binding | cation binding | D1 dopamine receptor binding | protein kinase binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | syntaxin binding | nucleotide binding | ATP-dependent protein binding | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | Ras GTPase binding | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | dopamine receptor binding | ATPase activity, coupled | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | G-protein coupled receptor binding | hydrolase activity, acting on acid anhydrides | small GTPase binding | Rab GTPase binding | SNARE binding | purine ribonucleotide binding | PDZ domain binding | adenyl ribonucleotide binding | drug binding | syntaxin-1 binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | protein C-terminus binding | glutamate receptor binding | ionotropic glutamate receptor binding | small molecule binding
GO Biological Process
neurotransmitter secretion | protein localization to cell periphery | regulation of localization | organelle fusion | establishment of localization | membrane fusion | positive regulation of receptor recycling | positive regulation of protein catabolic process | Golgi vesicle docking | membrane organization | intracellular transport | SNARE complex disassembly | cellular process | secretion | localization | protein transport | metal ion transport | chemical synaptic transmission | macromolecule localization | membrane docking | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | Golgi to plasma membrane transport | regulation of cellular process | regulation of metabolic process | organelle localization | cellular component organization | positive regulation of protein metabolic process | intracellular protein transport | establishment of protein localization to plasma membrane | regulation of receptor internalization | cellular localization | secretion by cell | cell-cell signaling | regulation of neurotransmitter levels | protein localization to plasma membrane | regulation of receptor-mediated endocytosis | post-Golgi vesicle-mediated transport | protein localization to membrane | organic substance transport | synaptic signaling | positive regulation of cellular metabolic process | monovalent inorganic cation transport | regulation of nitrogen compound metabolic process | peptide transport | vesicle-mediated transport | potassium ion transport | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | cellular protein complex disassembly | Golgi vesicle transport | vesicle fusion | establishment of protein localization to membrane | Golgi to plasma membrane protein transport | regulation of exocytosis | regulation of protein catabolic process | cellular protein localization | amide transport | regulation of vesicle-mediated transport | regulation of secretion | vesicle docking | establishment of protein localization | vesicle organization | signaling | regulation of endocytosis | protein localization | protein-containing complex disassembly | cation transport | cellular macromolecule localization | organelle organization | regulation of transport | regulation of receptor recycling | neurotransmitter transport | signal release | positive regulation of metabolic process | ion transport | regulation of cellular component organization | positive regulation of signaling | regulation of signaling
GO Cellular Component
Golgi stack | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cell | cytoplasm | intracellular organelle | dendritic tree | presynapse | Golgi apparatus | cell projection | endomembrane system | postsynapse | plasma membrane | postsynaptic density | asymmetric synapse | membrane-bounded organelle | dendritic shaft | organelle | postsynaptic specialization | cell periphery | cytosol | intracellular | myelin sheath | membrane
