QuickView for NAALAD2 (gene)

Gene Symbol:

NAALAD2 Homo sapiens

Full name:

N-acetylated alpha-linked acidic dipeptidase 2

Synonyms:

GCPIII, GPCIII, NAADALASE2, NAALADASE2, N-acetylated-alpha-linked acidic dipeptidase 2, N-acetylated alpha-linked acidic dipeptidase II, NAALADase II, glutamate carboxypeptidase III

Genomic Location:

Chr 11: 89507530-89565424

Description:

This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-...

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This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTAAR_UNKNOWN

Cytogenetic Map:

11q14.3

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