QuickView for NCOA2 (gene)

Gene Symbol:

NCOA2 Homo sapiens

Full name:

nuclear receptor coactivator 2

Synonyms:

GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2, class E basic helix-loop-helix protein 75, glucocorticoid receptor-interacting protein-1, p160 steroid receptor coactivator 2, transcriptional intermediary factor 2

Genomic Location:

Chr 8: 71186821-71478574

Description:

The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response ...

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The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  MAZR_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  LYF1_01 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  GGGYGTGNY_UNKNOWN ,  AP2_Q6_01 ,  ATTCTTT_MIR186 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  ATATGCA_MIR448 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IK2_01 ,  IK1_01 ,  TGCTTTG_MIR330 ,  ZF5_B ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  ACACTGG_MIR199A_MIR199B ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-137

miRNA binding sites
(Source: miRecords):

hsa-miR-137 Targeted Genes

Cytogenetic Map:

8q13.3

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